35692-27-4

Usage

Uses

Used in Pharmaceutical and Organic Synthesis Processes:
4-Methoxyphenyltrimethoxysilane is used as a reagent and intermediate in pharmaceutical and organic synthesis processes. Its unique chemical structure allows it to participate in various chemical reactions, contributing to the synthesis of complex organic molecules and pharmaceutical compounds.
Used in Surface Treatment Industry:
In the surface treatment industry, 4-Methoxyphenyltrimethoxysilane is used as a coupling agent for promoting adhesion between different materials. Its ability to form strong bonds with various surfaces, such as glass, metal, and plastic, makes it an ideal choice for enhancing the durability and performance of coatings, sealants, and adhesives.
Used in Chemical Binding Applications:
4-Methoxyphenyltrimethoxysilane is employed as a chemical binding agent in various applications. Its reactivity allows it to form stable bonds with different substrates, making it suitable for use in the production of composite materials, resins, and other chemical formulations.

InChI:InChI=1/C10H16O4Si/c1-11-9-5-7-10(8-6-9)15(12-2,13-3)14-4/h5-8H,1-4H3

Upstream product

• 67-56-1 methanol 
• 705-34-0 trichloro-(4-methoxyphenyl)silane 
• 2487-90-3 trimethoxysilane 
• 696-62-8 para-iodoanisole 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 681-84-5 tetramethylorthosilicate 

Downstream Products

• 56504-12-2 4-methoxyphenylsilatrane 
• 255835-92-8 (4-tert-butylphenyl)(4-methoxyphenyl)amine 
• 136608-30-5 1-(2-cyclohexylethyl)-4-methoxybenzene 
• 603984-42-5 4-(4-methoxy-phenyl)-nonan-2-one 
• 2132-80-1 4,4'-Dimethoxybiphenyl 
• 53040-92-9 4-(4-tolyl)anisole 
• 5958-02-1 3-(4-methoxyphenyl)pyridine 
• 2143-90-0 4-methoxy-4'-nitrobiphenyl 
• 792942-87-1 2-[(4-methoxyphenyl)methyl]succinic acid dimethyl ester 
• 356031-48-6 4′-methoxy-[1,1′-biphenyl]-4-yl 4-methylbenzenesulfonate 
• 27331-33-5 1-(4-methoxyphenyl)naphthalene 
• 17171-17-4 4'-methoxy-3-methylbiphenyl 
• 7380-78-1 4-(phenylethynyl)anisole 
• 59115-45-6 2-(4-methoxyphenyl)naphthalene 

Relevant academic research and scientific papers

Carbon-Silicon Bond Formation in the Synthesis of Benzylic Silanes

Sterically encumbered organosilanes can be difficult to synthesize with conventional, strongly basic reagents; the harsh reaction conditions are often low yielding and not suitable for many functional groups. As an alternative to the typical anionic strat

Improved synthesis of aryltrialkoxysilanes via treatment of aryl Grignard or lithium reagents with tetraalkyl orthosilicates

General reaction conditions for the synthesis of aryl(trialkoxy)silanes from aryl Grignard and lithium reagents and tetraalkyl orthosilicates (Si(OR)4) have been developed. Ortho-, meta-, and para-substituted bromoarenes underwent efficient metalation and silylation at low temperature to provide aryl siloxanes. Mixed results were obtained with heteroaromatic substrates: 3-bromothiophene, 3-bromo-4-methoxypyridine, 5-bromoindole, and N-methyl-5-bromoindole underwent silylation in good yield, whereas a low yield of siloxane was obtained from 2-bromofuran, and 2-bromopyridine failed to give silylated product. The synthesis of siloxanes via organolithium and magnesium reagents was limited by the formation of di- and triarylated silanes (Ar 2Si(OR)2 and Ar3SiOR, respectively) and dehalogenated (Ar-H) byproducts. Silylation at low temperature gave predominantly monoaryl siloxanes, without requiring a large excess of the electrophile. Optimal reaction conditions for the synthesis of siloxanes from aryl Grignard reagents entailed addition of arylmagnesium reagents to 3 equiv of tetraethyl- or tetramethyl orthosilicate at -30 °C in THF. Aryllithium species were silylated using 1.5 equiv of tetraethyl- or tetramethyl orthosilicate at -78 °C in ether.

Preparation of functionalized biaryl compounds via cross-coupling reactions of aryltrialkoxysilanes with aryl bromides

Aryltrimethoxysilanes react with aryl bromides in the presence of fluoride ion and palladium catalysts to give the corresponding biaryl compounds in good yields with high chemoselectivity.