35692-32-1

Upstream product

• 681-84-5 tetramethylorthosilicate 
• 76-13-1 1,1,2-Trichloro-1,2,2-trifluoroethane 
• 402-43-7 p-trifluoromethylphenyl bromide 

Downstream Products

• 603984-45-8 4-(4-trifluoromethyl-phenyl)-nonan-2-one 
• 92917-54-9 1-(1,2,2-trifluoroethenyl)-4-(trifluoromethyl)benzene 
• 867293-91-2 N-((1s,3s)-adamantan-1-yl)-4-(trifluoromethyl)benzamide 
• 115933-15-8 2-(4-(trifluoromethyl)phenyl)thiophene 
• 1608124-61-3 1-(pyrimidin-2-yl)-2-(4-(trifluoromethyl)phenyl)-1H-indole 
• 1174895-53-4 2-(4′-(trifluoromethyl)-[1,1′-biphenyl]-2-yl)pyridine 
• 741709-14-8 1-methyl-2-(4-(trifluoromethyl)phenyl)-1H-indole 
• 460743-71-9 2-(4-(trifluoro-methyl)phenyl)naphthalene 
• 80245-34-7 4-nitro-4’-(trifluoromethyl)biphenyl 
• 426823-25-8 3-(4-trifluoromethyl-phenyl)-pyridine 

Relevant academic research and scientific papers

Direct Hiyama Cross-Coupling of (Hetero)arylsilanes with C(sp2)-H Bonds Enabled by Cobalt Catalysis

We report a chelation-assisted C-H arylation of various indoles with sterically and electronically diverse (hetero)arylsilanes enabled by cost-effective Cp*-free cobalt catalysis. Key to the success of this strategy is the judicious choice of copper(II) fluoride as a bifunctional sliane activator and catalyst reoxidant. This methodology features a broad substrate scope and good functional group compatibility. The synthetic versatility of this protocol has been highlighted by the gram-scale synthesis and late-stage diversification of biologically active molecules.

Directed palladium(II)-catalyzed intermolecular anti-markovnikov hydroarylation of unactivated alkenes with (hetero)arylsilanes

We describe herein a regioselective palladium(II)catalyzed intermolecular hydroarylation of unactivated aliphatic alkenes with electronically and sterically diverse (hetero)arylsilanes under redox-neutral conditions. A removable bidentate 8-amino-quinoline auxiliary was readily employed to dictate the regioselectivity, prevent β-hydride elimination, and facilitate protodepalladation. This silicon-based protocol features a broad substrate scope with excellent functional group compatibility and enables an expeditious route to a variety of γ-aryl butyric acid derivatives in good yields with exclusive anti-Markovnikov selectivity.

Thermally stable, fluorine-containing organsilanes

A class of organosilanes of the general formula STR1 wherein Ar is a divalent aromatic radical; Rf is a defined fluoroalkyl or perfluoroalkyl ether group; X is methyl, Rf Ar as defined above, a halogen other than fluorine, or an alko