117490-58-1

Upstream product

• 13246-46-3 2,4-dibenzyloxybenzaldehyde 
• 33106-48-8 1-deoxy-1-[(2,6-dioxo-1,2,3,6-tetrahydro-4-pyrimidinyl)amino]-D-ribitol 
• 117490-57-0 4-(benzyloxy)-2-chlorobenzaldehyde 
• 100-44-7 benzyl chloride 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 56962-11-9 2-chloro-4-hydroxybenzaldehyde 
• 100-39-0 benzyl bromide 

Downstream Products

• 128858-15-1 8-benzyloxy-7,8-didemethyl-5-deazariboflavin 2',3',4'-triacetate 5'-trityl ether 
• 117490-60-5 Acetic acid (1S,2S,3R)-2,3-diacetoxy-1-(8-benzyloxy-2,4-dioxo-3,4-dihydro-2H-pyrimido[4,5-b]quinolin-10-ylmethyl)-4-hydroxy-butyl ester 

Relevant academic research and scientific papers

First Total Synthesis of Redox Coenzyme Factor 420

The first total synthesis of Methanobacterium redox coenzyme Factor 420 (F20) has been achieved by the formation of a phosphotriester bond between a protected 10-D-ribityl-8-hydroxy-5-deazaisoalloxazine moiety and a peptide moiety, (L-lactate-γ-L-glutamyl)-L-glutamic acid tribenzyl ester, by the phosphite triester approach using β,β,β-trichloroethyl phosphorodichloridite, followed by successive deprotection.

Synthesis of a Proposed Isomer of F420 having α-Glutamyl Bonding.

A proposed isomer of redox coenzyme F420 having α-glutamyl bonding, has been synthesized from 8-benzyloxy-10-D-ribityl-5-deazaflavin and α-L-glutamyl-L-glutamic acid moiety, by the phosphite triester approach followed by deprotection procedures.

First total synthesis of coenzyme factor 420

The first total synthesis of Methanobacterium redox coenzyme Factor 420 (F420) has been achieved by the formation of a phosphotriester bond between a protected 8-hydroxy-10-D-ribityl-5-deazaisoalloxazine moiety and a peptide moiety, (L-lactoyl-γ-L-glutamyl)-L-glutamic acid tribenzyl ester, by the phosphite triester approach using 2,2,2-trichloroethyl phosphorodichloridite, followed by successive deprotection procedures.