1175005-61-4Relevant academic research and scientific papers
Novel metronidazole-sulfonamide derivatives as potent and selective carbonic anhydrase inhibitors: Design, synthesis and biology analysis
Wang, Zhong-Chang,Duan, Yong-Tao,Qiu, Han-Yue,Huang, Wan-Yun,Wang, Peng-Fei,Yan, Xiao-Qiang,Zhang, Shu-Feng,Zhu, Hai-Liang
, p. 33029 - 33038 (2014)
Metronidazole-sulfonamide derivatives 4a-4l, a new class of human carbonic anhydrase inhibitors (hCA), were designed, synthesized, isolated, and evaluated for their ability to inhibit the enzymatic activity of the physiologically dominant isozymes hCA II
Metronidazole hydrazone conjugates: Design, synthesis, antiamoebic and molecular docking studies
Ansari, Mohammad Fawad,Siddiqui, Shadab Miyan,Agarwal, Subhash M.,Vikramdeo, Kunwar Somesh,Mondal, Neelima,Azam, Amir
, p. 3545 - 3549 (2015)
Abstract Metronidazole hydrazone conjugates (2-13) were synthesized and screened in vitro for antiamoebic activity against HM1: IMSS strain of Entamoeba histolytica. Six compounds were found to be better inhibitors of E. histolytica than the reference dru
Synthesis of metronidazole based thiazolidinone analogs as promising antiamoebic agents
Ansari, Mohammad Fawad,Inam, Afreen,Ahmad, Kamal,Fatima, Shehnaz,Agarwal, Subhash M.,Azam, Amir
, (2020/10/12)
Metronidazole and its derivatives are widely used for the treatment of amoebiasis. However, metronidazole is considered as the standard drug but it has many side effects. The present study describes the synthesis of a series of metronidazole based thiazolidinone analogs via Knoevenagel condensation of 4-[2-(2-methyl-5-nitro-1H-imidazole-1-yl)ethoxy]benzaldehyde 1 with various thiazolidinone derivatives 2–14 to get the new scaffold (15–27) having better activity and lesser toxicity. Six compounds have shown better efficacy and lesser cytotoxicity than the standard drug metronidazole towards HM1: IMSS strain of Entamoeba histolytica. These compounds may combat the problem of drug resistance and might be effective in identifying potential alternatives for future drug discovery against EhOASS.
Metronidazole-isatin type compound as well as preparation method and application thereof
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, (2016/10/09)
The invention discloses a metronidazole-isatin type compound as well as a preparation method and an application thereof. The compound has a structure represented by a formula (I) (shown in the specification). The preparation method comprises the following
Metronidazole derivatives as antiparasitic agents
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Page/Page column 8, (2009/08/16)
2-methyl-5-nitro-imidazolyl compounds with the general formula I, II or III: wherein one of the groups R1, R2, R3, R4, R5 is selected from an aldehyde and a 5- or 6-membered aromatic heterocylic group
