30575-42-9

Basic information

• Product Name: 1H-Imidazole-1-ethanol, 2-methyl-5-nitro-, 4-methylbenzenesulfonate (ester)
• CAS NO: 30575-42-9
• Molecular Formula: C13H15N3O5S
• Molecular Weight: 325.345
• Mol File: 30575-42-9.mol
• Article Data: 23

Chemical Properties

• CAS DataBase Reference: 1H-Imidazole-1-ethanol, 2-methyl-5-nitro-, 4-methylbenzenesulfonate (ester)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole-1-ethanol, 2-methyl-5-nitro-, 4-methylbenzenesulfonate (ester)(30575-42-9)
• EPA Substance Registry System: 1H-Imidazole-1-ethanol, 2-methyl-5-nitro-, 4-methylbenzenesulfonate (ester)(30575-42-9)

Safety Data

• Hazardous Substances Data: 30575-42-9(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 443-48-1 metronidazole 

Downstream Products

• 5006-79-1 2-methyl-5-nitro-1-vinylimidazole 
• 1241384-53-1 2-(4-bromophenyl)-1-(3-hydroxy-4-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethoxy)phenyl)ethanone 
• 1241384-59-7 1-(3-hydroxy-4-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethoxy)phenyl)-2-(4-nitrophenyl)ethanone 
• 1241384-57-5 1-(2-hydroxy-4-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethoxy)phenyl)-2-(4-methoxyphenyl)ethanone 
• 1241384-51-9 2-(4-chlorophenyl)-1-(2-hydroxy-4-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethoxy)phenyl)ethanone 
• 1241384-60-0 1-(2-hydroxy-4-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethoxy)phenyl)-2-(4-nitrophenyl)ethanone 
• 1241384-48-4 2-(4-fluorophenyl)-1-(2-hydroxy-4-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethoxy)phenyl)ethanone 
• 1241384-58-6 1-(2,3-dihydroxy-4-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethoxy)phenyl)-2-(4-methoxyphenyl)ethanone 
• 1241384-61-1 1-(2,3-dihydroxy-4-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethoxy)phenyl)-2-(4-nitrophenyl)ethanone 
• 1241384-54-2 2-(4-bromophenyl)-1-(2-hydroxy-4-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethoxy)phenyl)ethanone 
• 1241384-49-5 1-(2,3-dihydroxy-4-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethoxy)phenyl)-2-(4-fluorophenyl)ethanone 
• 1241384-52-0 2-(4-chlorophenyl)-1-(2,3-dihydroxy-4-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethoxy)phenyl)ethanone 
• 1194667-55-4 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl-5-methyl-2-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethoxy)benzoate 
• 1194667-57-6 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl-5-chloro-2-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethoxy)benzoate 

Relevant articles and documents

Preparation and biological evaluation of metronidazole derivatives with monoterpenes and eugenol

Two series of metronidazole derivatives (ester derivatives and ether derivatives) were prepared reacting metronidazole and its acetic acid oxidized form with menthol, thymol, carvacrol, and eugenol. Both series of compounds were tested in vitro against tw

Synthesis of metronidazole based thiazolidinone analogs as promising antiamoebic agents

Metronidazole and its derivatives are widely used for the treatment of amoebiasis. However, metronidazole is considered as the standard drug but it has many side effects. The present study describes the synthesis of a series of metronidazole based thiazolidinone analogs via Knoevenagel condensation of 4-[2-(2-methyl-5-nitro-1H-imidazole-1-yl)ethoxy]benzaldehyde 1 with various thiazolidinone derivatives 2–14 to get the new scaffold (15–27) having better activity and lesser toxicity. Six compounds have shown better efficacy and lesser cytotoxicity than the standard drug metronidazole towards HM1: IMSS strain of Entamoeba histolytica. These compounds may combat the problem of drug resistance and might be effective in identifying potential alternatives for future drug discovery against EhOASS.

Synthesis, Biological Evaluation, Structure-Activity Relationship, and Mechanism of Action Studies of Quinoline-Metronidazole Derivatives Against Experimental Visceral Leishmaniasis

In our efforts to identify novel chemical scaffolds for the development of antileishmanial agents, a series of quinoline-metronidazole hybrid compounds was synthesized and tested against the murine model of visceral leishmaniasis. Among all synthesized de