1175146-65-2

Basic information

• Product Name: 1-(2-azidoethyl)azepane
• Synonyms: 1-(2-azidoethyl)azepane
• CAS NO: 1175146-65-2
• Molecular Formula: C8H16N4
• Molecular Weight: 168.23944
• Mol File: 1175146-65-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2-azidoethyl)azepane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-azidoethyl)azepane(1175146-65-2)
• EPA Substance Registry System: 1-(2-azidoethyl)azepane(1175146-65-2)

Safety Data

• Hazardous Substances Data: 1175146-65-2(Hazardous Substances Data)

Usage

General Description

1-(2-azidoethyl)azepane is a chemical compound with the molecular formula C8H16N4. It is a member of the azide family of organic compounds, which contain the azide functional group (-N3). 1-(2-azidoethyl)azepane is a clear, colorless liquid at room temperature and is commonly used in organic synthesis and as a building block for the preparation of other chemical compounds. It has a six-membered ring structure with an azide group located at the end of a two-carbon chain, leading to its name "1-(2-azidoethyl)azepane." Due to the presence of the azide group, this compound is potentially hazardous and should be handled with care to avoid accidents and exposure.

Upstream product

• 51388-00-2 2-azepan-1-ylethylamine 
• 111-49-9 hexamethylene imine 
• 20603-00-3 2-(hexamethyleneimino)ethanol 
• 26487-67-2 1-(2-chloroethyl)azepane hydrochloride 

Relevant articles and documents

TEAD???YAP Interaction Inhibitors and MDM2 Binders from DNA-Encoded Indole-Focused Ugi Peptidomimetics

DNA-encoded combinatorial synthesis provides efficient and dense coverage of chemical space around privileged molecular structures. The indole side chain of tryptophan plays a prominent role in key, or “hot spot”, regions of protein–protein interactions. A DNA-encoded combinatorial peptoid library was designed based on the Ugi four-component reaction by employing tryptophan-mimetic indole side chains to probe the surface of target proteins. Several peptoids were synthesized on a chemically stable hexathymidine adapter oligonucleotide “hexT”, encoded by DNA sequences, and substituted by azide-alkyne cycloaddition to yield a library of 8112 molecules. Selection experiments for the tumor-relevant proteins MDM2 and TEAD4 yielded MDM2 binders and a novel class of TEAD-YAP interaction inhibitors that perturbed the expression of a gene under the control of these Hippo pathway effectors.

Side chain impacts on pH- and thermo-responsiveness of tertiary amine functionalized polypeptides

The systemic investigation of the structural impacts of side chains on the pH- and thermo-responsiveness of tertiary amine functionalized poly(l-glutamate)s (TA-PGs) was carried out. The TA-PGs polymers were effectively synthesized by Cu(I)-catalyzed azide-alkyne cycloaddition click reaction of azido tertiary amines with poly(γ-propargyl-l-glutamate) (PPLG). Turbimetric measurements were performed to characterize the pH- and temperature-induced phase transition of TA-PGs in aqueous solution, which suggested a structural dependence of the properties on the N-substituted groups and the "linkers" between 1,2,3-triazole ring and the tertiary amine groups in the side chains. In detail, the pH responsive properties of TA-PGs were basically determined by the hydrophobicity of the N-substituted groups in the side chains and the pH transition point (pHt) decreased as the increasing hydrophobicity of the N-substituted groups, while the temperature-responsiveness of TA-PGs were affected by either the N-substituted groups or the "linkers." TA-PGs with a moderate N-substituted amine group (e.g., DEA, PR, and PD) or a branched "linker" (e.g., iso-propylene and 2-methylpropylene group) were more likely to express the LCST-type phase transition tuned by pH variation. These structure-property relationships revealed in this study would help to develop the applications of TA-PGs in smart drug delivery systems. Copyright