88050-24-2

Upstream product

• 133042-41-8 α-tert-butyl γ-methyl N-(4-nitrobenzoyl)-L-glutamate 
• 133042-42-9 α-tert-butyl N-(4-nitrobenzoyl)-L-glutamate 
• 122-04-3 4-nitro-benzoyl chloride 
• 79640-72-5 L-glutamic acid 1-tert-butyl ester 5-methyl ester 
• 32719-56-5 tri-tert-butyl N--L-glutamate 
• 88063-78-9 L-γ-glutamyl-L-glutamic acid tris-t-butyl ester 
• 32677-01-3 L-glutamic acid di-tert-butyl ester hydrochloride 
• 5891-45-2 (S)-2-(benzyloxycarbonylamino)pentanedioic acid tert-butyl ester 
• 117559-38-3 tri-tert-butyl N-benzoyl>-L-γ-glutamyl>-L-glutamate 
• 133042-43-0 tri-tert-butyl N-(4-nitrobenzoyl)-γ-L-glutamyl-L-glutamate 

Downstream Products

• 133042-47-4 tri-tert-butyl <4-<<(2-amino-3-cyanopyrazin-5-yl)methyl>amino>benzoyl>-γ-L-glutamyl-L-glutamate 
• 117559-52-1 tri-tert-butyl N-prop-2-ynylamino>benzoyl>-L-γ-glutamyl>-L-glutamate 
• 117559-48-5 tri-tert-butyl N-prop-2-ynylamino>benzoyl>-L-γ-glutamyl>-L-glutamate 
• 117581-21-2 tri-tert-butyl N--L-γ-glutamyl>-L-glutamate 

Relevant academic research and scientific papers

Quinazoline Antifolates Inhibiting Thymidylate Synthase: Synthesis of Four Oligo(L-γ-glutamyl) Conjugates of N10-Propargyl-5,8-dideazafolic Acid and Their Enzyme Inhibition

The synthesis is described of four oligo(γ-glutamyl) conjugates of N10-propargyl-5,8-dideazafolic acid containing a total of two, three, four, and five L-glutamic acid residues.The tert-butyl group was chosen as the carboxyl protecting group in