1739-00-0Relevant articles and documents
β-phenylethylamines, indolines and isoquinolones via hydroamination of styrenes by microwave irradiation
Seijas,Vázquez-Tato,Martínez
, p. 875 - 877 (2001)
Microwave irradiation promotes hydroamination of styrenes. This method can be used as a direct way of producing different kinds of bioactive compounds: open chain compounds like β-phenylethylamines or cyclized products like indolines or isoquinolones.
Anti-Markovnikov hydroaminations of styrene catalyzed by palladium(II) N-heterocyclic carbene complexes under conventional and microwave heating
G?k, Yetkin,Yi?it, Beyhan,?zero?lu ?elikal, ?zlem,Yi?it, Murat
, p. 591 - 596 (2018)
Six palladium(II) complexes with benzimidazole-based N-heterocyclic carbene ligands were synthesized by transmetallation reactions between silver(I) N-heterocyclic carbene complexes and PdCl2(PhCN)2. The complexes were characterized by physicochemical and spectroscopic methods. The palladium complexes were tested as catalysts for intermolecular hydroamination reactions of styrene with various anilines in ionic liquids under both conventional and microwave heating. All of these complexes proved to be catalytically active in these reactions. The anti-Markovnikov addition products were selectively obtained by using 1?mol% of the palladium complex.
Titanium amido- and imido-complexes supported by a tridentate pyrrolyl ligand: Syntheses, characterisation and catalytic activities
Chen, Zhou,Li, Lei,Chen, Yanmei,Hu, Bin,Wu, Jian,Wang, Xiufang,Lei, Tao,Li, Yahong
, p. 249 - 253 (2012)
The complexes [Ti(NMe2)2(pmpmi)] [H2pmpmi = (2-pyrrolylmethene)-(2-pyrrolylmethyl)imine], [Ti(NtBu)(pmpmi)(py) 2], [Ti(NtBu)(pmpmi)(dpy)] and [Ti(NPh)(pmpmi)(py) 2] have been prepared, characterised and shown to be pre-catalysts for the hydroamination of phenylacetylene with aniline and p-chloroaniline. The X-ray structures of [Ti(NMe2)2(pmpmi)], [Ti(N tBu)(pmpmi)(dpy)] and [Ti(NPh)(pmpmi)(py)2] have been determined.
Minimization of Back-Electron Transfer Enables the Elusive sp3 C?H Functionalization of Secondary Anilines
Zhao, Huaibo,Leonori, Daniele
supporting information, p. 7669 - 7674 (2021/03/08)
Anilines are some of the most used class of substrates for application in photoinduced electron transfer. N,N-Dialkyl-derivatives enable radical generation α to the N-atom by oxidation followed by deprotonation. This approach is however elusive to monosubstituted anilines owing to fast back-electron transfer (BET). Here we demonstrate that BET can be minimised by using photoredox catalysis in the presence of an exogenous alkylamine. This approach synergistically aids aniline SET oxidation and then accelerates the following deprotonation. In this way, the generation of α-anilinoalkyl radicals is now possible and these species can be used in a general sense to achieve divergent sp3 C?H functionalization.
Deglycase-activity oriented screening to identify DJ-1 inhibitors
David, Yael,Finkin-Groner, Efrat,Fukase, Yoshiyuki,Huggins, David J.,Maksimovic, Igor,Michino, Mayako,Myers, Robert W.,Sun, Shan,Zheng, Qingfei
supporting information, p. 1232 - 1238 (2021/09/28)
The oncoprotein and Parkinson's disease-associated enzyme DJ-1/PARK7 has emerged as a promiscuous deglycase that can remove methylglyoxal-induced glycation adducts from both proteins and nucleotides. However, dissecting its structural and enzymatic functions remains a challenge due to the lack of potent, specific, and pharmacokinetically stable inhibitors targeting its catalytic site (including Cys106). To evaluate potential drug-like leads against DJ-1, we leveraged its deglycase activity in an enzyme-coupled, fluorescence lactate-detection assay based on the recent understanding of its deglycation mechanism. In addition, we developed assays to directly evaluate DJ-1's esterase activity using both colorimetric and fluorescent substrates. The resulting optimized assay was used to evaluate a library of potential reversible and irreversible DJ-1 inhibitors. The deglycase activity-oriented screening strategy described herein establishes a new platform for the discovery of potential anti-cancer drugs.
A base-free Chan–Lam reaction catalyzed by an easily assembled Cu(II)-carboxylate metal-organic framework
Ma, Ruixuan,Qin, Jianhua,Shi, Lei,Zhang, Xinhai
, p. 795 - 799 (2021/07/06)
A new copper(II) metal-organic framework is constructed as a sustainable copper heterogeneous catalyst. Cu-DPTCA, with high catalytic activity, can effectively promote the Chan–Lam coupling reaction of arylboronic acids and amines without adding any base or additive.