117560-10-8

Basic information

• Product Name: 4-Imidazolidinecarboxylicacid, 3-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]-2-oxo-,(4S)-
• Synonyms: 4-Imidazolidinecarboxylicacid, 3-[2-[(1-carboxy-3-phenylpropyl)amino]-1-oxopropyl]-2-oxo-,[4S-[3[R*(R*)],4R*]]-; 6366DM
• CAS NO: 117560-10-8
• Molecular Formula: C17H21 N3 O6
• Molecular Weight: 363.37
• Mol File: 117560-10-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Imidazolidinecarboxylicacid, 3-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]-2-oxo-,(4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Imidazolidinecarboxylicacid, 3-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]-2-oxo-,(4S)-(117560-10-8)
• EPA Substance Registry System: 4-Imidazolidinecarboxylicacid, 3-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]-2-oxo-,(4S)-(117560-10-8)

Safety Data

• Hazardous Substances Data: 117560-10-8(Hazardous Substances Data)

Upstream product

• 117560-17-5 (S)-3-[(S)-2-((S)-1-Benzyloxycarbonyl-3-phenyl-propylamino)-propionyl]-2-oxo-imidazolidine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester 
• 117560-15-3 (S)-2-((S)-1-tert-Butoxycarbonyl-ethylamino)-4-phenyl-butyric acid benzyl ester; compound with (Z)-but-2-enedioic acid 
• 117560-24-4 p-tolylsulfonic caid salt of L-homophenylalanine benzyl ester 
• 117560-14-2 N-<1(S)-(benzyloxycarbonyl)-3-phenylpropyl>-L-alanine tert-butyl ester 
• 89371-42-6 (2S)-2-amino>propionic acid 
• 943-73-7 D-homophenylalanine 
• 5440-40-4 2-(acetylamino)-4-phenylbutanoic acid 
• 1012-05-1 D,L-homophenylalanine 
• 16503-46-1 2-bromo-4-phenyl butanoic acid 
• 117560-18-6 (S)-3-[(S)-2-((S)-1-Benzyloxycarbonyl-3-phenyl-propylamino)-propionyl]-2-oxo-imidazolidine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester; compound with (Z)-but-2-enedioic acid 

Relevant articles and documents

Studies on Angiotensin Converting Enzyme Inhibitors. 4. Synthesis and Angiotensin Converting Enzyme Inhibitory Activities of 3-Acyl-1-alkyl-2-oxoimidazolidine-4-carboxylic Acid Derivatives

(4S)-1-Alkyl-3-acyl>-2-oxoimidazolidine-4-carboxylic acid derivatives (3) were prepared by two methods.Their angiotensin converting enzyme (ACE) inhibitory activities and antihypertensive effects were evaluated, and the structure-activity relationships were discussed.The dicarboxylic acids 3a-n possessing S,S,S configuration showed potent in vitro ACE inhibitory activities with IC 50 values of 1.1x10-8-1.5x10-9 M.The most potent compound in this series, monoester 3p, had an ID 50 value of 0.24 mg/kg, po for inhibition of angiotensin I induced pressor response in normotensive rats and produced a dose-dependent decrease in systolic blood pressure of spontaneously hypertensive rats (SHRs) at doses of 1-10 mg/kg, po.