117560-95-9

Basic information

• Product Name: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-,3'-methanesulfonate
• Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-,3'-methanesulfonate
• CAS NO: 117560-95-9
• Molecular Formula: C31H32N2O9S
• Molecular Weight: 608.669
• Mol File: 117560-95-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-,3'-methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-,3'-methanesulfonate(117560-95-9)
• EPA Substance Registry System: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-,3'-methanesulfonate(117560-95-9)

Safety Data

• Hazardous Substances Data: 117560-95-9(Hazardous Substances Data)

Usage

General Description

Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-,3'-methanesulfonate is a chemical compound that is a derivative of uridine, a naturally occurring nucleoside. Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-,3'-methanesulfonate is a sulfonated uridine analog that is often used in scientific research and pharmaceutical development. It is known for its potential therapeutic applications, particularly in the treatment of neurological disorders and as a modulator of RNA function. Additionally, it has been studied for its anti-tumor and anti-inflammatory properties. The chemical structure of this compound includes a modified uridine base with bis(4-methoxyphenyl)phenylmethyl groups attached to the 5'-O position and a methanesulfonate group attached to the 3' position, giving it unique properties and biological activities.

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 951-78-0 2'-deoxyuridine 
• 23669-79-6 DMT-dU 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 184241-35-8 1-{(2R,4S,5S)-4-Azido-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-4-(2-nitro-phenoxy)-1H-pyrimidin-2-one 
• 170236-33-6 3'-azido-N₄-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2',3'-dideoxycytidine 
• 184241-37-0 4-Amino-1-{(2R,4S,5S)-4-azido-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-1H-pyrimidin-2-one 
• 158846-98-1 5'-O-dimethoxytrityl-3'-azido-2',3'-dideoxyuridine 
• 170236-36-9 5'-O-(4,4'-dimethoxytrityl)-2,3'-anhydro-2'-deoxyuridine 

Relevant articles and documents

PROCESS FOR PREPARING DISULPHIDES AND THIOSULPHINATES AND COMPOUNDS PREPARED

Process for preparing a compound of the formula (I) R1-S(O)x—S(O)yR2 in which R1 represents a molecular hydrocarbon radical which can be substituted and/or interrupted by one or more atoms and/or by one or more groups containing one or more atoms, said atoms being selected from N, O, P, S, Si and X, where X represents a halogen; R2, independently of R1, represents a carbon-containing group or a molecular hydrocarbon radical which can be substituted and/or interrupted by one or more atoms and/or by one or more groups containing one or more atoms, said atoms being selected from N, O, P, S, Si and X, where X represents a halogen, and x and y are selected from 0 and 1 in such a way that the sum of x and y is not more than 1, characterized in that a compound of formula (II) R1-S(O)x—R3-Si(R4)(R5)(R6) in which R3 represents a hydrocarbon chain of two carbon atoms, which is optionally unsaturated and/or substituted, and R4, R5 and R6, which are identical or different, each represent, independently of one another, a hydrocarbon group, is reacted with a compound of formula (VII) R2-S(O)y—X in which X represents a halogen, intermediate compounds, and compounds prepared.

New carbamate supports for the preparation of 3'-amino-modified oligonucleotides

A novel approach for the preparation of oligonucleotides carrying amino groups at the 3'-end is described. Several CPG supports having aminoalkyl groups and 3'-amino-2',3'-dideoxynucleosides linked through base-labile carbamate linkages such as 2-(2- nitrophenyl)ethoxycarbonyl and fluorenylmethoxycarbonyl were prepared using two different strategies. These supports are compatible to the standard solid phase phosphite-triester methodology and yield oligonucleotides containing amino groups at the 3'-end. Several properties of the 3'-amino oligonucleotides, such as nuclease resistance, hybridization, and preparation of oligonucleotide conjugates are discussed.