170236-33-6

Upstream product

• 98-88-4 benzoyl chloride 
• 184241-37-0 4-Amino-1-{(2R,4S,5S)-4-azido-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-1H-pyrimidin-2-one 
• 23669-79-6 DMT-dU 
• 158846-98-1 5'-O-dimethoxytrityl-3'-azido-2',3'-dideoxyuridine 
• 170236-36-9 5'-O-(4,4'-dimethoxytrityl)-2,3'-anhydro-2'-deoxyuridine 
• 124930-55-8 3’-azido N4-benzoyl 2’-deoxycytidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 184241-35-8 1-{(2R,4S,5S)-4-Azido-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-4-(2-nitro-phenoxy)-1H-pyrimidin-2-one 
• 117560-95-9 Methanesulfonic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 
• 951-78-0 2'-deoxyuridine 

Relevant academic research and scientific papers

Convenient syntheses of 3′-amino-2′,3′- dideoxynucleosides, their 5′-monophosphates, and 3′-aminoterminal oligodeoxynucleotide primers

(Chemical Equation Presented) 5′-Protected 3′-amino-2′, 3′-dideoxynucleosides containing any of the four canonical nucleobases (A/C/G/T) were prepared via azides in five to six steps, starting from deoxynucleosides. For pyrimidines, the synthetic route in

New carbamate supports for the preparation of 3'-amino-modified oligonucleotides

A novel approach for the preparation of oligonucleotides carrying amino groups at the 3'-end is described. Several CPG supports having aminoalkyl groups and 3'-amino-2',3'-dideoxynucleosides linked through base-labile carbamate linkages such as 2-(2- nitrophenyl)ethoxycarbonyl and fluorenylmethoxycarbonyl were prepared using two different strategies. These supports are compatible to the standard solid phase phosphite-triester methodology and yield oligonucleotides containing amino groups at the 3'-end. Several properties of the 3'-amino oligonucleotides, such as nuclease resistance, hybridization, and preparation of oligonucleotide conjugates are discussed.