117601-23-7

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 108-94-1 cyclohexanone 
• 106763-17-1 4-methoxybenzylidenecyanothioacetamide 
• 5765-29-7 E-2-(4-methoxybenzylidene)cyclohexanone 
• 7357-70-2 Cyanothioacetamide 

Downstream Products

• 117601-33-9 3-Amino-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-thieno[2,3-b]quinoline-2-carboxylic acid methyl ester 
• 117601-28-2 [3-Cyano-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-quinolin-2-ylsulfanyl]-acetic acid ethyl ester 
• 117601-32-8 3-Amino-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-thieno[2,3-b]quinoline-2-carboxylic acid amide 
• 720676-74-4 2-[3-cyano-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-quinolin-2-ylsulfanyl]-N-phenyl-acetamide 
• 720676-68-6 3-amino-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-thieno[2,3-b]quinoline-2-carboxylic acid phenylamide 
• 906375-54-0 3-amino-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-thieno[2,3-b]quinoline-2-carboxylic acid (4-methoxy-phenyl)-amide 
• 117601-31-7 3-amino-4-(p-anisyl)-5,6-tetramethylenethieno[2,3-b]pyridine-2-carbonitrile 
• 351532-52-0 11-(p-methoxyphenyl)-2-phenacylthio-7,8,9,10-hexahydropyrimido[4',5':4,5]thieno[2,3-b]quinolin-3(4H)-one 

Relevant academic research and scientific papers

Design, Synthesis, and In Vitro Antileishmanial and Antitumor Activities of New Tetrahydroquinolines

A novel series of tetrahydroquinolines containing acetohydrazide, oxopyrazole, oxothioxodihydropyrazole, and thioxotriazole have been synthesized. Antileishmanial, antitumor, and cytotoxicity activities of synthesized compounds were evaluated in vitro. Antileishmanial activity of the most synthesized compounds showed tremendous activity towards Leishmania major. Most of the test compounds exhibited significant level of tumor inhibition. The tetrahydropyrano[2,3-b]quinolin-2-one 6 and 4-oxo-4H-pyrazol-3-yloxytetrahydroquinoline-3-carbonitrile derivatives 18 showed 100% tumor inhibition comparable with standard drug vincristine (100% tumor inhibition). Tetrahydroquinolines under investigation showed cytotoxicity with LD50 values in the range 0.56–3.01?μg/mL compared with standard drug MS-222 with LD50 value of 4.30?μg/mL. The presence of a pyrazole ring markedly improved the activity profiles of tetrahydroquinoline. All newly synthesized compounds were characterized by IR, 1H NMR, and MS.

STUDIES ON ALKYLHETEROAROMATIC COMPOUNDS. THE REACTIVITY OF ALKYL POLYFUNCTIONALLY SUBSTITUTED AZINES TOWARDS ELECTROPHILIC REAGENTS

Several new alkylpyridine, pyridazine and pyrimidine derivatives are synthesized from acyclic intermediates.The reactivity of these alkylazines towards aromatic aldehydes and arylidenemalononitrile is reported.New synthesis for substituted phthalazines ci