117601-31-7

Upstream product

• 107-14-2 chloroacetonitrile 
• 117601-23-7 4-(4-methoxyphenyl)-2-sulfanylidene-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 5765-29-7 E-2-(4-methoxybenzylidene)cyclohexanone 
• 117601-27-1 2-Cyanomethylsulfanyl-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-quinoline-3-carbonitrile 

Downstream Products

• 753478-73-8 3-amino-4-(p-anisyl)-5,6-tetramethylenethieno[2,3-b]pyridine-3-(N-amino)amidine 

Relevant academic research and scientific papers

Synthesis of some new fused azines of expected bio-responses

4-Anisy1-5,6-polymethylene-3-cyanopyridine-2(1H)-thiones 1 were reacted with chloroacetonitrile in alcoholic KOH to give theino[2,3- b]pyridine derivatives 2. Enaminonitriles 2 were reacted with each of HCOOH, formamide / HCOOH / DMF mixture and cyanamide / HCl to give 3, 4, and 5, respectively, whereas boiling 2 in a proper solvent and basic catalyst with each of CS 2 and thiourea yielded 6 and 7 respcetively. On the other hand, fused pyridine derivatives 8, 9, and 10 were obtained by re fluxing 2 with each of malononitrile, ethyl cyanoacetate, and benzalmalononitrile in alcoholic triethylamine mixture. Also, fused pyrazoles and benzo-1,4-diazepines 12 and 14 were synthesized.