1176030-91-3Relevant academic research and scientific papers
Synthesis and biological activities of 5-thio-α-GALCERS
Bi, Jingjing,Wang, Jing,Zhou, Kai,Wang, Yuancheng,Fang, Min,Du, Yuguo
, p. 476 - 480 (2015)
NKT cells, a unique subset of T cells that recognizes glycolipid antigens presented by CD1d molecules, are believed to produce key cytokines of both Th1 and Th2 T cells and are thus involved in the control of several types of immune response. As an active glycolipid antigen having α-galactosyl ceramide core structure, KRN7000 showed promising immunostimulation activity and was selected as an anticancer drug candidate for further clinical application. In this report, three new KRN7000 structural analogues were designed and synthesized, in which the ring oxygen of the galactopyranose residue is replaced by a sulfur atom along with the variation on the lipid chain. Their abilities for stimulating mouse NKT cells to produce IFN-γ and IL-4 were evaluated both in vivo and in vitro.
Facile synthesis of biotin-labelled α-galactosylceramide as antigen for invariant natural killer T cells
Xia, Chengfeng,Zhang, Wenpeng,Zhang, Yalong,Woodward, Robert L.,Wang, Jinhua,Wang, Peng G.
experimental part, p. 6390 - 6395 (2009/12/06)
When iNKT cells are stimulated by the CD1d presented exogenous α-galactosylceramide, a myriad of cytokines are released that trigger a variety of immune responses. However, the invisibility and poor aqueous solubility of α-galactosylceramide during bioass
