117606-92-5Relevant articles and documents
Synthesis and thermotropic properties of novel double-chained quaternary ammonium chlorides with symmetric and asymmetric hydrocarbon chain length
Ding, Zhaoyun,Hao, Aiyou
, p. 127 - 131 (2009)
A series of novel double-chained quaternary ammonium chlorides with symmetrical and asymmetrical hydrocarbon chain length R1-O-CH2-CH(OH)-CH2-N+(CH3)2-R2·Cl- (R1, R2: C12H25, C14H29, C16H33) have been synthesized by the reaction of 1-O-alkyl glycidyl ether with N,N-dimethylalkylamine and N,N-dimethylalkylamine hydrochloride. Their chemical structures have been characterized through FT-IR, 1H NMR, MS and elementary analysis. Their thermotropic properties have been examined by differential scanning calorimetry (DSC), polarizing light microscopy (PLM) and X-ray diffraction (XRD). It has been found that the compounds with longer hydrocarbon chain length and being higher asymmetry in hydrocarbon chain length exhibit lower melting point (Tm), isotropization temperature (Ti) and narrower mesophase temperature range. However, the hydrocarbon chain length and the symmetry in the hydrocarbon chain length have little influence on the type of liquid crystals. All compounds form cholesteric liquid crystal.
Influence of α-branched fatty acid chains on the thermotropic behaviour of racemic 1-O-hexadecyl-2-acyl-glycero-3-phosphocholines
Rattay, Bernd,Brezesinski, Gerald,Dobner, Bodo,Foerster, Guenter,Nuhn, Peter
, p. 81 - 92 (1995)
Phosphatidylcholines containing an α-branched palmitic acid ester linked to position C2 of the glycerol backbone were synthesized and characterized using differential scanning calorimetry and X-ray diffraction. As the length of the sidegroup substituted on the palmitic acid chain is changed, the calorimetric parameters pass through a minimum. The polymorphic behaviour is different when the sidegroup is larger, or smaller, than propyl. The comparison of the physicochemical parameters of isomers differing in the bonding of the branched chain fatty acid to the glycerol backbone (to position C1 or C2, respectively) shows that the chains are nonequivalent. Keywords: Phosphatidylcholine; Branched chain fatty acids; Microcalorimetry; X-ray diffraction; Polymorphism
Physicochemical properties of novel phosphobetaine zwitterionic surfactants and mixed systems with an anionic surfactant
Nong, Lanping,Xiao, Chengliang,Zhong, Zhensheng
, p. 433 - 438 (2011)
A series of novel zwitterionic phosphobetaine (PPBT) surfactants were synthesized using long chain fatty alcohol, epichlorohydrin, dimethylamine and sodium dihydrogen phosphate as raw materials. The physicochemical properties of the phosphobetaine surfactants such as isoelectric point, foaming, surface tension, critical micelle concentration (CMC) and Krafft point were measured. Low CMC and surface tension values indicated the surface activities of the phosphobetaine surfactants were quite excellent. The CMC and surface tension values of PPBT/SDS mixed systems were determined. It was found both of CMC and surface tension values decreased compared with single surfactant system because of the association between dodecyl sulfate anions and cationic groups in phosphobetaine by electrostatic attraction. AOCS 2011.
Synthesis, characterization and evaluation of the surface active properties of novel cationic imidazolium gemini surfactants
Patial, Pankaj,Shaheen, Arifa,Ahmad, Ishtiaque
, p. 253 - 260 (2014)
New imidazolium gemini surfactants were synthesized by reaction of epichlorohydrin with long chain fatty alcohols furnishing products 2-(alkoxymethyl)oxirane followed by their subsequent treatment with imidazole resulting in the formation of 1-(1H-imidazol-1-yl-3 alkoxy)propane-2-ol which on subsequent treatment with 1,2-dibromoethane and 1,3-dibromopropane resulted in the formation of title gemini surfactants:1,2-bis(1(3-alkoxy-2-hydroxypropyl)- 1H-imidazol-3-ium)ethane bromide (7), 1,3-bis(1(3-alkoxy-2-hydroxypropyl)-1H- imidazol-3-ium)propane bromide (8), 1,2-bis(1(3-alkoxy-2-hydroxypropyl)-1H- imidazol-3-ium)ethane bromide (9), 1,3-bis(1(3-alkoxy-2-hydroxypropyl)-1H- imidazol-3-ium)propane bromide (10), 1,2-bis (1(3-alkoxy-2-hydroxypropyl)-1H- imidazol-3-ium)ethane bromide (11) and 1,3-bis (1(3-alkoxy-2-hydroxypropyl)-1H- imidazol-3-ium)propane bromide (12). Their identification was based on IR, 1H-, 13C-NMR, DEPT, COSY and mass spectral studies. Their surface active properties were also evaluated on the basis of surface tension and conductivity measurements.
Synthesis, Surface and Antimicrobial Activities of Novel Cationic Gemini Surfactants
Ding, Zhaoyun,Fang, Shimin
, p. 1051 - 1057 (2015)
A series of novel cationic gemini surfactants [C n H2n+1-O-CH2-CH(OH)-CH2-N+(CH3)2-(CH2)2]2·2Br- [3a (n = 12), 3b (n = 14) and 3c (n = 16)] having a 2-hydroxy-1,3-oxypropylene group [-CH2-CH(OH)-CH2-O-] in the hydrophobic chain have been synthesized and characterized. Their water solubility, surface activity, foaming properties, and antibacterial activity have been examined. The critical micelle concentration (CMC) values of the novel cationic gemini surfactants are one to two orders of magnitude smaller than those of the corresponding monomeric surfactants. Furthermore, the novel cationic gemini surfactants have better water solubility and surface activity than the comparable [C n H2n+1-N+(CH3)2-(CH2)2]2·2Br- (n-4-n) geminis. The novel cationic gemini surfactants 3a and 3b also exhibit good foaming properties and show good antibacterial and antifungal activities.
Synthesis method of amide derivative
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Paragraph 0016; 0041-0042; 0045-0046, (2021/02/06)
The invention relates to the field of organic synthesis, and discloses a synthesis method of an amide derivative. The synthesis method comprises the following steps: generating glycidyl ether from alkyl alcohol and epoxy chloropropane under the actions of alkali and a catalyst, and carrying out aminolysis on the glycidyl ether and ethanolamine to obtain a secondary amine derivative; and carrying out aminolysis on the secondary amine derivative and alkyl carboxylic acid methyl ester to obtain the amide derivative. The synthesis method disclosed by the invention is simple, short in synthesis route, short in product production period and high in economic benefit, the total yield of the product is 45 to 55%, and the purity is up to 98%.
Synthesis of natural 1- O -alkylglycerols: A study on the chemoselective opening of the epoxide ring by onium quaternary salts (N and P) and ionic liquids
Nascimento, Thiana Santiago,Braga, Esther Faria,Casaes Gomes, Giselle Cristina,Batista, William Rom?o,Mazzei Albert, André Luís,Capella Lopes, Rosangela Sabbatini,Lopes, Claudio Cerqueira
, p. 1050 - 1054 (2020/01/23)
A chemoselective route for the synthesis of 1-O-alkylglycerols chimyl (1), batyl (2), and selachyl (3) is reported. These compounds can be naturally isolated from shark liver oil and the skin of animals such as stingrays and chimeras and exhibit potential anti-fouling activity. The synthetic approach developed in this work included two distinct methods of preparation. The first was based on solvent-free reactions catalyzed by onium quaternary salts (N and P) and ionic liquids; the second methodology was based on a series of one-pot reactions.
LIPID COMPOUNDS FOR SUPRESSION OF TUMORIGENESIS
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Page/Page column 33, (2010/04/03)
The present invention provides compounds, or pharmaceutically acceptable salts or analogs thereof, which exhibit anti-tumor activity. The present invention also includes methods for inhibiting the growth of cancer cells by contacting an effective amount of a compound of the present invention with the cancer cells in vitro or in vivo.
Single step etherification of fatty alcohols by an epihalohydrin
Najem,Borredon
, p. 3021 - 3030 (2007/10/02)
A new, single step synthesis of glycidyl ethers from an epihalohydrin (X = Cl, Br) and seven fatty alcohols is proposed in a poorly hydrated solid/liquid heterogeneous basic medium. The selectivity and the yields of the reaction are high. The structural analysis and the physicochemical characteristics of the synthesized products are reported.
