117612-53-0Relevant academic research and scientific papers
7-Methoxyfuro[2,3-c]pyridine-4-carboxamides as PDE4 inhibitors: A potential treatment for asthma
Buckley, George M.,Cooper, Nicola,Davenport, Richard J.,Dyke, Hazel J.,Galleway, Fiona P.,Gowers, Lewis,Haughan, Alan F.,Kendall, Hannah J.,Lowe, Christopher,Montana, John G.,Oxford, Janet,Peake, Joanna C.,Picken,Richard, Marianna D.,Sabin, Verity,Sharpe, Andrew,Warneck, Julie B.H.
, p. 509 - 512 (2007/10/03)
The synthesis and pharmacological profile of a novel series of 7-methoxy-furo[2,3-c]pyridine-4-carboxamides is described. Some of these compounds were found to be potent inhibitors of phosphodiesterase type 4 (PDE4). Initial
Furopyridines. XXIII [1]. Synthesis and Reactions of Chloropyridine Derivatives of Furo[2,3-b]-, -[2,3-c]- and -[3,2-c]pyridine
Shiotani, Shunsaku,Taniguchi, Katsunori
, p. 925 - 929 (2007/10/03)
Chlorination of the N-oxides of furo[2,3-b]- 1a, -[2,3-c]- 1b and -[3,2-c]pyridine 1c with phosphorus oxychloride afforded compounds substituted normally at the α- or γ-position to the ring nitrogen, 2a, 2′a, 2b, 2c, 2′c and 2″c, and in addition, in the case of 1b, compounds substituted on the furan ring, 2′b and 2″b. The structures of these compounds were confirmed from their ir, nmr and mass spectra. The major chlorinated products 2a, 2b and 2c were converted to methoxy- 5a, 5b and 5c, N-pyrrolidyl- 7a, 7b and 7c, and phenylthiofuropyridines 8a, 8b, and 8c.
