117654-35-0

Basic information

• Product Name: 1H-Imidazole-1-carboxamide, N-(4-chlorophenyl)-
• CAS NO: 117654-35-0
• Molecular Formula: C10H8ClN3O
• Molecular Weight: 221.646
• Mol File: 117654-35-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1H-Imidazole-1-carboxamide, N-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole-1-carboxamide, N-(4-chlorophenyl)-(117654-35-0)
• EPA Substance Registry System: 1H-Imidazole-1-carboxamide, N-(4-chlorophenyl)-(117654-35-0)

Safety Data

• Hazardous Substances Data: 117654-35-0(Hazardous Substances Data)

Usage

Antifungal medication

Clotrimazole is used to treat various fungal infections.

Indications

It is used to treat yeast infections of the skin and vagina, jock itch, and ringworm.

Mechanism of action

Clotrimazole works by disrupting the cell membrane of the fungus, leading to the inhibition of its growth and replication.

Forms

It is available in various forms, including cream, lotion, and solution.

Dosage

It is typically applied to the affected area 2-3 times daily for several weeks, or as directed by a healthcare professional.

Side effects

Common side effects include skin irritation or rash at the application site.

Contraindications

Clotrimazole should not be ingested and is not effective for the treatment of bacterial or viral infections.

Upstream product

• 106-47-8 4-chloro-aniline 
• 530-62-1 1,1'-carbonyldiimidazole 
• 104-12-1 p-chlorphenylisocyanate 
• 18156-74-6 1-(Trimethylsilyl)imidazole 
• 288-32-4 1H-imidazole 

Downstream Products

• 1547120-60-4 C₂₃H₁₉Cl₂N₅O₂ 
• 2617-79-0 N-(4-chlorophenyl)formamide 
• 1415662-05-3 ethyl 4-(4-(3-(4-chlorophenyl)ureido)phenoxy)benzoate 
• 1415662-14-4 methyl 3-(4-(3-(4-chlorophenyl)ureido)phenoxy)benzoate 
• 1967-26-6 N-(4-chlorophenyl)-N'-phenylurea 
• 288-32-4 1H-imidazole 
• 104-12-1 p-chlorphenylisocyanate 
• 1203-77-6 1-(4-chloro-phenyl)-3-methyl-1,3-dihydro-imidazol-2-one 
• 139109-17-4 1-(N-p-chlorophenyl)-2-(N-phenyl)imidazole-1,2-dicarboxamide 
• 1415662-00-8 3-(4-(3-(4-chlorophenyl)ureido)phenoxy)-N-hydroxybenzamide 
• 1415662-18-8 3-(4-(3-(4-chlorophenyl)ureido)phenoxy)benzoic acid 
• 1415661-95-8 C₂₀H₁₆ClN₃O₄ 
• 1415662-10-0 4-(4-(3-(4-chlorophenyl)ureido)phenoxy)benzoic acid 

Relevant articles and documents

Design, synthesis and biological evaluation of indole derivatives as novel inhibitors targeting B-Raf kinase

A series of novel indole derivatives were designed and synthesized and their inhibitory activity against B-Raf and HepG2 cell were also described. Among them, compounds 7a and 7b exhibited excellent potency, which showed the potential for further research

Synthesis and antitumor activity of novel diaryl ether hydroxamic acids derivatives as potential HDAC inhibitors

A series of diaryl ether hydroxamic acids were synthesized for the first time and evaluated for the HDAC biology and antiproliferative activity. The structures of these new hydroxamic acids derivatives were confirmed by IR, 1H-NMR and mass spectrum. Some of these compounds showed micro molar activity in the HDAC inhibitory assay and against four cancer cell lines.

REACTIONS OF ISOTHIOCYANATES AND ISOCYANATES WITH SOME SILYLATED NITROGEN-CONTAINING NUCLEOPHILES

Aryl isothiocyanates and arylisocyanates react with N,O-bis(trimethylsilyl)acetamide to give N-methyl-N'-arylthioureas and ureas.Also nucleophilic additions of other aprotic nucleophiles (e.g.N-trimethylsilylimidazole, N-trimethylsilylpiperidine and N-trimethylsilylmorpholine) to the N=C=X (X=O,S) group were investigated.