117659-22-0Relevant academic research and scientific papers
Intramolecular SH2 macrocyclisations
Baldwin, Jack E.,Adlington, Robert M.,Mitchell, Mark B.,Robertson, Jeremy
, p. 5901 - 5918 (2007/10/02)
The synthesis of 10-15 membered α-methylene macrocyclic lactones from the functionalised allylstannanes (7e)-(7j) is described. Attempts to synthesise analogous 6-9 membered lactones proved unsuccessful, resulting instead in the production of dilactones and AIBN derived adducts.
Radical Reactions in Synthesis: Intramolecular SH2' Macrocyclisations
Baldwin, Jack E.,Adlington, Robert M.,Mitchell, Mark B.,Robertson, Jeremy
, p. 1574 - 1575 (2007/10/02)
The synthesis of 10-15 membered α-methylene lactones 1 from the functionalised allyl stannanes 2 occurs cleanly in moderate to high yield under free radical conditions via an intramolecular SH2' reaction.
SIMPLE SYNTHESIS OF α-METHYLENE ESTERS AND AMIDES FROM METHACRYLIC DERIVATIVES VIA TOSYLATED INTERMEDIATES
Najera, Carmen,Mancheno, Balbino,Yus, Miguel
, p. 3837 - 3840 (2007/10/02)
α-(Tosylmethyl)acrylic acid methyl ester or N-isopropylamide (obtained by a tandem iodosulfonylation-dehydroiodination of methyl methacrylate or N-isopropylacrylamide) react with Grignard reagents or sodium diethyl malonate to give the corresponding α-met
Regio- and Stereo-selective Synthesis of β-Sulphonyl-α,β-Unsaturated Carbonyl Compounds via an Iodosulphonylation-Dehydroiodination Raction
Najera, Carmen,Baldo, Beatriz,Yus, Miguel
, p. 1029 - 1032 (2007/10/02)
α,β-Unsaturated carbonyl compounds underwent regiospecific iodosulphonylation with toluene-p-sulphonyl iodide or sodium toluene-p-sulphinate and iodine to afford products (2), which were stereoselectively dehydroiodinated by triethylamine to give β-sulphonyl derivatives (3).The reactivity of compounds (3) as cationic β-acylvinyl equivalents, tested with amines or thiophenol, gave compounds (4) resulting from a displacement reaction.
