117693-24-0

Basic information

• Product Name: 5-(1-PROPYNYL)-2'-DEOXYCYTIDINE
• Synonyms: 5-(1-PROPYNYL)-2'-DEOXYCYTIDINE;5-PROPYNYL-2'-DEOXYCYTIDINE;2'-Deoxy-5-propynylcytidine
• CAS NO: 117693-24-0
• Molecular Formula: C₁₂H₁₅N₃O₄
• Molecular Weight: 265.27
• Mol File: 117693-24-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 509.3 ºCat 760 mmHg
• Flash Point: 261.8 ºC
• Appearance: /
• Density: 1.48 g/cm³
• CAS DataBase Reference: 5-(1-PROPYNYL)-2'-DEOXYCYTIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(1-PROPYNYL)-2'-DEOXYCYTIDINE(117693-24-0)
• EPA Substance Registry System: 5-(1-PROPYNYL)-2'-DEOXYCYTIDINE(117693-24-0)

Safety Data

• Hazardous Substances Data: 117693-24-0(Hazardous Substances Data)

Usage

General Description

5-(1-Propynyl)-2'-deoxycytidine (PCdC) is a modified nucleoside analog that has shown promise as a potential anticancer agent. This chemical compound has been studied for its ability to inhibit DNA synthesis and repair in cancer cells, making it a potential candidate for use in chemotherapy. PCdC has also been found to induce apoptosis in cancer cells and inhibit tumor growth in preclinical studies. Furthermore, it has been shown to have selectivity for cancer cells over normal cells, potentially reducing the toxicity associated with traditional chemotherapy. Its ability to target cancer cells while sparing normal cells makes it an attractive candidate for further development as a cancer treatment.

Upstream product

• 611-53-0 5-Iodo-2'-deoxycytidine 
• 74-99-7 prop-1-yne 
• 54-42-2 5-Iodo-2'-deoxyuridine 

Downstream Products

• 945537-40-6 4-amino-1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-(prop-1-ynyl)pyrimidin-2H-2-one 
• 945537-41-7 4-benzoylamino-1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-(prop-1-ynyl)pyrimidin-2H-2-one 
• 945537-43-9 4-acetylamino-1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-(prop-1-ynyl)pyrimidin-2H-2-one 
• 945537-45-1 4-[(dibutylaminomethylidene)amino]-1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-(prop-1-ynyl)pyrimidin-2H-2-one 

Relevant articles and documents

Inhibition of tumor necrosis factor alpha (TNFα) expression and function in vitro by modified antisense oligonucleotides

Antisense oligonucleotides containing C-5 hexynyl/propynyl modified pyrimidines were synthesized using solid phase phosphoramidite chemistry. These modified oligonucleotides were found to have significant inhibitory activity against TNFα production in vit

NANOPARTICLE NUCLEIC ACID BINDING COMPOUND CONJUGATES FORMING I-MOTIFS

The present invention concerns the field of nanoparticle bioconjugates which form an i-motif or an i-motif related structure (compositions) (i) without or (ii) with at least one further nucleic acid binding compound (Figure 1). The i-motif base pairs can

Antiviral compounds

The present invention relates to certain novel 5-substituted pyrimidine nucleosides and pharmaceutically acceptable derivatives thereof and their use in the treatment of varicella zoster virus, cytomegalovirus and Epstein Barr virus infections. Also provided are pharmaceutical formulations and processes for the preparation of the compounds according to the invention.