117693-24-0

Usage

Uses

Used in Pharmaceutical Industry:
5-(1-PROPYNYL)-2'-DEOXYCYTIDINE is used as a potential anticancer agent for its ability to inhibit DNA synthesis and repair in cancer cells, induce apoptosis, and inhibit tumor growth. Its selectivity for cancer cells over normal cells makes it a promising candidate for reducing the toxicity associated with traditional chemotherapy.
Used in Cancer Research:
5-(1-PROPYNYL)-2'-DEOXYCYTIDINE is used as a subject of preclinical studies to further investigate its potential as a cancer treatment and to explore its mechanisms of action in inhibiting DNA synthesis and repair, inducing apoptosis, and inhibiting tumor growth.
Used in Drug Development:
5-(1-PROPYNYL)-2'-DEOXYCYTIDINE is used as a candidate for the development of new cancer therapies, with the aim of improving treatment options and reducing side effects for patients undergoing chemotherapy.

Upstream product

• 54-42-2 5-Iodo-2'-deoxyuridine 
• 611-53-0 5-Iodo-2'-deoxycytidine 
• 74-99-7 prop-1-yne 

Downstream Products

• 945537-45-1 4-[(dibutylaminomethylidene)amino]-1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-(prop-1-ynyl)pyrimidin-2H-2-one 
• 945537-43-9 4-acetylamino-1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-(prop-1-ynyl)pyrimidin-2H-2-one 
• 945537-41-7 4-benzoylamino-1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-(prop-1-ynyl)pyrimidin-2H-2-one 
• 945537-40-6 4-amino-1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-(prop-1-ynyl)pyrimidin-2H-2-one 

Relevant academic research and scientific papers

Inhibition of tumor necrosis factor alpha (TNFα) expression and function in vitro by modified antisense oligonucleotides

Antisense oligonucleotides containing C-5 hexynyl/propynyl modified pyrimidines were synthesized using solid phase phosphoramidite chemistry. These modified oligonucleotides were found to have significant inhibitory activity against TNFα production in vit

Oligodeoxynucleotides Containing C-5 Propyne Analogs of 2'-Deoxyuridine and 2'-Deoxycytidine

Oligodeoxynucleotides (ODN) containing 5-(1-propynyl)-2'-deoxyuridine and 5-(1-propynyl)-2'-deoxycytidine significantly enhance double-helix formation with single strand RNA and 5-(1-propynyl)-2'-deoxyuridine significantly enhances triple-helix formation with double stranded DNA.

NANOPARTICLE NUCLEIC ACID BINDING COMPOUND CONJUGATES FORMING I-MOTIFS

The present invention concerns the field of nanoparticle bioconjugates which form an i-motif or an i-motif related structure (compositions) (i) without or (ii) with at least one further nucleic acid binding compound (Figure 1). The i-motif base pairs can

Oligonucleotides forming an i-motif: The pH-dependent assembly of individual strands and branched structures containing 2′-deoxy-5- propynylcytidine

Non-branched and branched oligonucleotides incorporating consecutive runs of 2′-deoxy-5-propynylcytidine residues (2) instead of 2′-deoxycytidine (1) were synthesized. For this, phosphoramidite building blocks of 2′-deoxy-5-propynylcytidine (3a-c) were pr

Antiviral compounds

The present invention relates to certain novel 5-substituted pyrimidine nucleosides and pharmaceutically acceptable derivatives thereof and their use in the treatment of varicella zoster virus, cytomegalovirus and Epstein Barr virus infections. Also provided are pharmaceutical formulations and processes for the preparation of the compounds according to the invention.