Inhibition of tumor necrosis factor alpha (TNFα) expression and function in vitro by modified antisense oligonucleotides

Article abstract of DOI:10.1080/07328319708006259

Antisense oligonucleotides containing C-5 hexynyl/propynyl modified pyrimidines were synthesized using solid phase phosphoramidite chemistry. These modified oligonucleotides were found to have significant inhibitory activity against TNFα production in vit

Full text of DOI:10.1080/07328319708006259

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Nucleosides and Nucleotides
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Inhibition of Tumor Necrosis Factor
Alpha (TNFα) Expression and Function
In Vitro by Modified Antisense
Oligonucleotides
a
a
a
Joshua O. Ojwang , T. Sudhakar Rao , Hélène B. Marshall
a
a
a
,
Shawn D. Mustain , Nilabh Chaudhary , David A. Walker ,
b
b
a
Anusch Peyman , Eugen Uhlmann , Ganapathi R. Revankar &
a
Robert F. Rando
a
Aronex Pharmaceuticals, Inc. , 9391 Grogans Mill Road, The
Woodlands, TX, 77380, USA
b
Hoechst Marion Roussel , G838, D-65926, Frankfurt, Germany
Published online: 16 Aug 2006.
To cite this article: Joshua O. Ojwang , T. Sudhakar Rao , Hélène B. Marshall , Shawn D. Mustain ,
Nilabh Chaudhary , David A. Walker , Anusch Peyman , Eugen Uhlmann , Ganapathi R. Revankar &
Robert F. Rando (1997) Inhibition of Tumor Necrosis Factor Alpha (TNFα) Expression and Function
In Vitro by Modified Antisense Oligonucleotides, Nucleosides and Nucleotides, 16:7-9, 1703-1707,
DOI: 10.1080/07328319708006259
To link to this article: http://dx.doi.org/10.1080/07328319708006259
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