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1177-87-3

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Product FOB Price Min.Order Supply Ability Supplier
Manufactuered in China Dexamethasone-17-acetate
Cas No: 1177-87-3
No Data 100 Gram Metric Ton/Day Wuhan Zenuo Biological Medicine Technology Co Ltd Contact Supplier
High purity Various Specifications dexamethasone-21-acetate CAS:1177-87-3
Cas No: 1177-87-3
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
high quality dexamethasone-17-acetate bulk supply
Cas No: 1177-87-3
USD $ 80.0-100.0 / Kilogram 1 Kilogram 10 Metric Ton/Day Kono Chem Co.,Ltd Contact Supplier
Dexamethasone-17-acetate 1177-87-3
Cas No: 1177-87-3
USD $ 720.0-800.0 / Kilogram 1 Kilogram 10 Metric Ton/Month Hebei yanxi chemical co.,LTD. Contact Supplier
Dexamethasone-17-acetate cas 1177-87-3
Cas No: 1177-87-3
USD $ 1.0-1.0 / Gram 10 Gram 1 Metric Ton/Month Hebei Yingong New Material Technology Co.,Ltd . Contact Supplier
Wholesale High Quality Bulk Price Auxiron Powder
Cas No: 1177-87-3
USD $ 1.0-3.0 / Gram 10 Gram 5000 Kilogram/Month Xi'an Julong Bio-Tech Co., Ltd. Contact Supplier
4-(9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-3-hydroxy-4-oxobutanoate
Cas No: 1177-87-3
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
Dexamethasone 21-acetate
Cas No: 1177-87-3
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
Nice price pharmaceutical grade dexamethasone acetate powder 99% dexamethasone acetate
Cas No: 1177-87-3
USD $ 2.0-3.0 / Gram 10 Gram 1000 Kilogram/Month Shaanxi Greenyo Biotech Co., Ltd. Contact Supplier
Dexamethasone acetate
Cas No: 1177-87-3
No Data 5 Milligram Gram/Day Chengdu Lemeitian Pharmaceutical Technology Co,. Ltd Contact Supplier

1177-87-3 Usage

Uses

Protected Dexamethasone, a glucocorticoid anti-inflammatory agent.

Purification Methods

Dexamethasone 21-acetate is purified on neutral Al2O3 using CHCl3 as eluent, the fractions are evaporated, and the residue is recrystallised from CHCl3. It has max at 239nm. [Oliveto et al. J Am Chem Soc 8 0 4431 1958]. [Beilstein 8 IV 3501.]

Chemical Properties

Off-White Solid

Brand name

Decadron (Merck).
InChI:InChI=1/C24H31FO6/c1-13-9-18-17-6-5-15-10-16(27)7-8-21(15,3)23(17,25)19(28)11-22(18,4)24(13,30)20(29)12-31-14(2)26/h7-8,10,13,17-19,28,30H,5-6,9,11-12H2,1-4H3/t13-,17?,18?,19+,21+,22+,23+,24+/m1/s1

1177-87-3 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
USP (1176506)  Dexamethasone acetate  United States Pharmacopeia (USP) Reference Standard 1177-87-3 1176506-200MG 4,750.20CNY Detail
Sigma-Aldrich (D0710000)  Dexamethasone acetate  European Pharmacopoeia (EP) Reference Standard 1177-87-3 D0710000 1,880.19CNY Detail
Sigma-Aldrich (PHR1527)  Dexamethasone Acetate  pharmaceutical secondary standard; traceable to USP, PhEur 1177-87-3 PHR1527-1G 934.95CNY Detail
TCI America (D3628)  Dexamethasone 21-Acetate  >98.0%(HPLC) 1177-87-3 5g 1,420.00CNY Detail
TCI America (D3628)  Dexamethasone 21-Acetate  >98.0%(HPLC) 1177-87-3 1g 370.00CNY Detail

1177-87-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name Dexamethasone-17-acetate

1.2 Other means of identification

Product number -
Other names DEXAMETHASONE 21-ACETATE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1177-87-3 SDS

1177-87-3Synthetic route

21-acetoxy-9-fluoro-11β,17-dihydroxy-16α-methyl-pregn-4-ene-3,20-dione
1524-94-3

21-acetoxy-9-fluoro-11β,17-dihydroxy-16α-methyl-pregn-4-ene-3,20-dione

betamethasone
1177-87-3

betamethasone

Conditions
ConditionsYield
With selenium(IV) oxide
21-acetoxy-9,11β-epoxy-17-hydroxy-16α-methyl-9β-pregna-1,4-diene-3,20-dione
912-38-9, 2884-51-7, 14622-51-6, 98573-86-5

21-acetoxy-9,11β-epoxy-17-hydroxy-16α-methyl-9β-pregna-1,4-diene-3,20-dione

betamethasone
1177-87-3

betamethasone

Conditions
ConditionsYield
With tetrahydrofuran; chloroform; hydrogen fluoride
17α,21-dihydroxy-9β,11β-epoxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate
2884-51-7

17α,21-dihydroxy-9β,11β-epoxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate

betamethasone
1177-87-3

betamethasone

Conditions
ConditionsYield
With hydrogen fluoride In N,N-dimethyl-formamide at -10℃; for 3h; Temperature;
With hydrogen fluoride In chloroform
16β-methyl-17a,11β,21-trihydroxy-9-bromopregna-4-ene-3,20-dione-21-acetate
34542-57-9

16β-methyl-17a,11β,21-trihydroxy-9-bromopregna-4-ene-3,20-dione-21-acetate

betamethasone
1177-87-3

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium acetate; ethanol
2: THF; CHCl3; HF
3: SeO2
View Scheme
21-acetoxy-9,11β-epoxy-17-hydroxy-16α-methyl-9β-pregn-4-ene-3,20-dione
18769-18-1, 34542-58-0, 104111-24-2, 104527-32-4

21-acetoxy-9,11β-epoxy-17-hydroxy-16α-methyl-9β-pregn-4-ene-3,20-dione

betamethasone
1177-87-3

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: THF; CHCl3; HF
2: SeO2
View Scheme
17,21-dihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione
19784-87-3

17,21-dihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione

betamethasone
1177-87-3

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: mit Hilfe von Pestalotia foedans
4: sodium acetate; acetic acid
5: N-bromo-acetamide; dichloromethane; tert-butyl alcohol / Reagens 4: wss. Perchlorsaeure, Erwaermen des Reaktionsprodukts mit Kaliumacetat in Aceton
6: CHCl3; THF; HF
View Scheme
21-acetoxy-17-hydroxy-16α-methyl-11α-(toluene-4-sulfonyloxy)-pregna-1,4-diene-3,20-dione
115606-30-9

21-acetoxy-17-hydroxy-16α-methyl-11α-(toluene-4-sulfonyloxy)-pregna-1,4-diene-3,20-dione

betamethasone
1177-87-3

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium acetate; acetic acid
2: N-bromo-acetamide; dichloromethane; tert-butyl alcohol / Reagens 4: wss. Perchlorsaeure, Erwaermen des Reaktionsprodukts mit Kaliumacetat in Aceton
3: CHCl3; THF; HF
View Scheme
11α,17,21-trihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione
78761-59-8

11α,17,21-trihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione

betamethasone
1177-87-3

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
3: sodium acetate; acetic acid
4: N-bromo-acetamide; dichloromethane; tert-butyl alcohol / Reagens 4: wss. Perchlorsaeure, Erwaermen des Reaktionsprodukts mit Kaliumacetat in Aceton
5: CHCl3; THF; HF
View Scheme
21-acetoxy-11α,17-dihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione
6242-16-6

21-acetoxy-11α,17-dihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione

betamethasone
1177-87-3

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
2: sodium acetate; acetic acid
3: N-bromo-acetamide; dichloromethane; tert-butyl alcohol / Reagens 4: wss. Perchlorsaeure, Erwaermen des Reaktionsprodukts mit Kaliumacetat in Aceton
4: CHCl3; THF; HF
View Scheme
17α,21-dihydroxy-16α-methyl-1,4,9(11)-pregnatriene-3,20-dione 21-acetate
10106-41-9

17α,21-dihydroxy-16α-methyl-1,4,9(11)-pregnatriene-3,20-dione 21-acetate

betamethasone
1177-87-3

betamethasone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-bromo-acetamide; dichloromethane; tert-butyl alcohol / Reagens 4: wss. Perchlorsaeure, Erwaermen des Reaktionsprodukts mit Kaliumacetat in Aceton
2: CHCl3; THF; HF
View Scheme
dexamethasone
50-02-2

dexamethasone

acetic anhydride
108-24-7

acetic anhydride

betamethasone
1177-87-3

betamethasone

Conditions
ConditionsYield
With sodium acetate In tetrahydrofuran; acetone at 40℃; for 5h; Inert atmosphere;
5-methylthiophene-2-carbonyl chloride
31555-59-6

5-methylthiophene-2-carbonyl chloride

betamethasone
1177-87-3

betamethasone

9α-fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-(5'-methyl-2'-thenoate) 21-acetate
83880-83-5

9α-fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-(5'-methyl-2'-thenoate) 21-acetate

Conditions
ConditionsYield
With dmap In dichloromethane; N,N-dimethyl-formamide for 72h; Ambient temperature;11%
betamethasone
1177-87-3

betamethasone

dexamethasone
50-02-2

dexamethasone

Conditions
ConditionsYield
In ethanol at 24 - 26℃; for 96h; Penicillium decumbens ATCC 10436, potato dextrose broth;5%
With methanol; sodium carbonate at 20℃; for 0.166667h; Temperature;
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

betamethasone
1177-87-3

betamethasone

9α-fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-(2'-furoate) 21-acetate
83880-70-0

9α-fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-(2'-furoate) 21-acetate

Conditions
ConditionsYield
With 4-pyrrolidin-1-ylpyridine In dichloromethane for 96h; Ambient temperature;2%
betamethasone
1177-87-3

betamethasone

A

Acetic acid (1R,3R,4aS,4bS,10aS,10bR,11S,12aS)-10b-fluoro-1,11-dihydroxy-3,10a,12a-trimethyl-2,8-dioxo-1,2,3,4,4a,4b,5,6,8,10a,10b,11,12,12a-tetradecahydro-chrysen-1-ylmethyl ester

Acetic acid (1R,3R,4aS,4bS,10aS,10bR,11S,12aS)-10b-fluoro-1,11-dihydroxy-3,10a,12a-trimethyl-2,8-dioxo-1,2,3,4,4a,4b,5,6,8,10a,10b,11,12,12a-tetradecahydro-chrysen-1-ylmethyl ester

B

Acetic acid (2S,3R,4aS,4bS,10aS,10bR,11S,12aS)-10b-fluoro-2,11-dihydroxy-3,10a,12a-trimethyl-1,8-dioxo-1,2,3,4,4a,4b,5,6,8,10a,10b,11,12,12a-tetradecahydro-chrysen-2-ylmethyl ester

Acetic acid (2S,3R,4aS,4bS,10aS,10bR,11S,12aS)-10b-fluoro-2,11-dihydroxy-3,10a,12a-trimethyl-1,8-dioxo-1,2,3,4,4a,4b,5,6,8,10a,10b,11,12,12a-tetradecahydro-chrysen-2-ylmethyl ester

Conditions
ConditionsYield
With tin(IV) chloride In acetonitrile for 3h; Ambient temperature;
betamethasone
1177-87-3

betamethasone

9α-fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-(2'-furoate) 21-propionate
83880-75-5

9α-fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-(2'-furoate) 21-propionate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 2 percent / 4-pyrrolidinopyridine (4-PP) / CH2Cl2 / 96 h / Ambient temperature
2: 99 percent / 70percent aq. HClO4 / methanol / 24 h / Ambient temperature
3: 68 percent / pyridine / 18 h / Ambient temperature
View Scheme
betamethasone
1177-87-3

betamethasone

9α-fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-(2'-furoate) 21-butyrate
83881-10-1

9α-fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-(2'-furoate) 21-butyrate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 2 percent / 4-pyrrolidinopyridine (4-PP) / CH2Cl2 / 96 h / Ambient temperature
2: 99 percent / 70percent aq. HClO4 / methanol / 24 h / Ambient temperature
3: 58 percent / pyridine
View Scheme
betamethasone
1177-87-3

betamethasone

9α-fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-(2'-furoate) 21-methoxyacetate
83880-97-1

9α-fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-(2'-furoate) 21-methoxyacetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 2 percent / 4-pyrrolidinopyridine (4-PP) / CH2Cl2 / 96 h / Ambient temperature
2: 99 percent / 70percent aq. HClO4 / methanol / 24 h / Ambient temperature
3: 68 percent / pyridine
View Scheme
betamethasone
1177-87-3

betamethasone

Furan-2-carboxylic acid (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11-hydroxy-17-(2-hydroxy-acetyl)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester
83880-74-4

Furan-2-carboxylic acid (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11-hydroxy-17-(2-hydroxy-acetyl)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 2 percent / 4-pyrrolidinopyridine (4-PP) / CH2Cl2 / 96 h / Ambient temperature
2: 99 percent / 70percent aq. HClO4 / methanol / 24 h / Ambient temperature
View Scheme
betamethasone
1177-87-3

betamethasone

21-chloro-11β,17α-dihydroxy-9α-fluoro-16α-methyl-1,4-pregnadiene-3,20-dione 17-(2'-furoate)
83880-77-7

21-chloro-11β,17α-dihydroxy-9α-fluoro-16α-methyl-1,4-pregnadiene-3,20-dione 17-(2'-furoate)

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 2 percent / 4-pyrrolidinopyridine (4-PP) / CH2Cl2 / 96 h / Ambient temperature
2: 99 percent / 70percent aq. HClO4 / methanol / 24 h / Ambient temperature
3: pyridine / 1 h / 0 - 2 °C
4: LiCl / dimethylformamide / 20 h / 80 °C
View Scheme
betamethasone
1177-87-3

betamethasone

Furan-2-carboxylic acid (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11-hydroxy-17-(2-methanesulfonyloxy-acetyl)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester
83880-76-6

Furan-2-carboxylic acid (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11-hydroxy-17-(2-methanesulfonyloxy-acetyl)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 2 percent / 4-pyrrolidinopyridine (4-PP) / CH2Cl2 / 96 h / Ambient temperature
2: 99 percent / 70percent aq. HClO4 / methanol / 24 h / Ambient temperature
3: pyridine / 1 h / 0 - 2 °C
View Scheme
betamethasone
1177-87-3

betamethasone

disodium dexamethasone-21-phosphate

disodium dexamethasone-21-phosphate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium carbonate; methanol / 0.17 h / 20 °C
2: pyrophosphoryl chloride / tetrahydrofuran
3: sodium hydroxide / methanol / 1 h / 20 °C
View Scheme
betamethasone
1177-87-3

betamethasone

dexamethasone phosphate
312-93-6, 360-63-4

dexamethasone phosphate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium carbonate; methanol / 0.17 h / 20 °C
2: pyrophosphoryl chloride / tetrahydrofuran
View Scheme

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