117710-72-2Relevant academic research and scientific papers
Selective Reductions. 52. Efficient Asymmetric Reduction of α-Acetylenic α'-Fluoroalkyl Ketones with Either B-Chlorodiisopinocampheylborane or B-Isopinocampheyl-9-borabicyclononane in High Enantiomeric Purity. The Influence of Fluoro Groups in Such
Ramachandran, P. Veeraraghavan,Gong, Baoqing,Teodorovic, Aleksandar V.,Brown, Herbert C.
, p. 1061 - 1074 (1994)
A systematic study of the asymmetric reduction of prochiral α-acetylenic α'-fluoroalkyl ketones with (-)-B-chlorodiisopinocampheylborane and (-)-B-isopinocampheyl-9-borabicyclononane (R-Alpine-Borane, 2) reveals that perfluoro
Direct and Chemoselective Synthesis of Tertiary Difluoroketones via Weinreb Amide Homologation with a CHF2-Carbene Equivalent
Miele, Margherita,Citarella, Andrea,Micale, Nicola,Holzer, Wolfgang,Pace, Vittorio
supporting information, p. 8261 - 8265 (2019/10/16)
The homologation of Weinreb amides into difluoromethylketones with a formal nucleophilic CHF2 transfer agent is reported. Activating TMSCHF2 with potassium tert-amylate enables a convenient access to the difluorinated homologation re
Copper-Mediated Deacylative Coupling of Ynones via C-C Bond Activation under Mild Conditions
Feng, Lili,Hu, Tingjun,Zhang, Saisai,Xiong, Heng-Ying,Zhang, Guangwu
supporting information, p. 9487 - 9492 (2019/12/02)
The intermolecular deacylative coupling of unstrained ynones via C-C bond activation was accomplished by a CuCl-bpy system under mild reaction conditions. This protocol features facile cleavage of the C-C bond at room temperature, broad substrate scope, and efficient construction of important symmetric and unsymmetrical 1,3-diyne adducts through homo or cross coupling of ynones, respectively. The preliminary mechanistic investigations indicated that an acyl copper(III) complex is likely involved in this process.
COMPOUNDS AND COMPOSITIONS AND USES THEREOF
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Paragraph 0157, (2018/02/28)
Compounds of formula (I) are disclosed, as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric diseases and disorders in a subject in need thereof are also disclosed.
Stereoselective synthesis of anti-α-(difluoromethyl)-β-amino alcohols by boronic acid based three-component condensation. Stereoselective preparation of (2S,3R)-difluorothreonine
Prakash, G. K. Surya,Mandal, Mihirbaran,Schweizer, Stefan,Petasis, Nicos A.,Olah, George A.
, p. 3718 - 3723 (2007/10/03)
Starting from optically active 3,3-difluorolactaldehyde, an alkenyl or aryl boronic acid, and an amine, a one-step three-component methodology was developed for the stereoselective preparation of anti-α-(difluoromethyl)-β-amino alcohols. β-Furyl-substituted anti-α-(difiuoromethyl)-β-amino alcohol was further elaborated to form (2S,3R)-difluorothreonine in high yield and ee.
Addition of Organocuprates to Acetylenic Di- and Trifluoromethyl Ketones. Regiospecific Synthesis of β,β-Disubstituted Unsaturated Fluoro ketones
Lindermann, Russel J.,Lonikar, Madhu S.
, p. 6013 - 6022 (2007/10/02)
A regiospecific synthesis of β,β-disubstituted-α,β-unsaturated di- and trifluoromethyl ketones has been achieved by the conjugate addition of higher order cyano cuprate reagents to acetylenic di- and trifluoromethyl ketones.An efficient and reproducible s
