117710-72-2Relevant articles and documents
Selective Reductions. 52. Efficient Asymmetric Reduction of α-Acetylenic α'-Fluoroalkyl Ketones with Either B-Chlorodiisopinocampheylborane or B-Isopinocampheyl-9-borabicyclononane in High Enantiomeric Purity. The Influence of Fluoro Groups in Such
Ramachandran, P. Veeraraghavan,Gong, Baoqing,Teodorovic, Aleksandar V.,Brown, Herbert C.
, p. 1061 - 1074 (1994)
A systematic study of the asymmetric reduction of prochiral α-acetylenic α'-fluoroalkyl ketones with (-)-B-chlorodiisopinocampheylborane and (-)-B-isopinocampheyl-9-borabicyclononane (R-Alpine-Borane, 2) reveals that perfluoro
Copper-Mediated Deacylative Coupling of Ynones via C-C Bond Activation under Mild Conditions
Feng, Lili,Hu, Tingjun,Zhang, Saisai,Xiong, Heng-Ying,Zhang, Guangwu
supporting information, p. 9487 - 9492 (2019/12/02)
The intermolecular deacylative coupling of unstrained ynones via C-C bond activation was accomplished by a CuCl-bpy system under mild reaction conditions. This protocol features facile cleavage of the C-C bond at room temperature, broad substrate scope, and efficient construction of important symmetric and unsymmetrical 1,3-diyne adducts through homo or cross coupling of ynones, respectively. The preliminary mechanistic investigations indicated that an acyl copper(III) complex is likely involved in this process.
Stereoselective synthesis of anti-α-(difluoromethyl)-β-amino alcohols by boronic acid based three-component condensation. Stereoselective preparation of (2S,3R)-difluorothreonine
Prakash, G. K. Surya,Mandal, Mihirbaran,Schweizer, Stefan,Petasis, Nicos A.,Olah, George A.
, p. 3718 - 3723 (2007/10/03)
Starting from optically active 3,3-difluorolactaldehyde, an alkenyl or aryl boronic acid, and an amine, a one-step three-component methodology was developed for the stereoselective preparation of anti-α-(difluoromethyl)-β-amino alcohols. β-Furyl-substituted anti-α-(difiuoromethyl)-β-amino alcohol was further elaborated to form (2S,3R)-difluorothreonine in high yield and ee.
