153801-13-9Relevant academic research and scientific papers
Convenient synthesis of difluoromethyl alcohols from both enolizable and non-enolizable carbonyl compounds with difluoromethyl phenyl sulfone
Prakash, G.K.Surya,Hu, Jinbo,Wang, Ying,Olah, George A.
, p. 2218 - 2223 (2005)
A general and efficient nucleophilic difluoromethylation of carbonyl compounds (both enolizable and non-enolizable aldehydes and ketones) has been achieved by using a nucleophilic (phenylsulfonyl)difluoromethylation-reductive desul fonylation strategy. Di
COMPOUNDS AND COMPOSITIONS AND USES THEREOF
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Paragraph 0157, (2018/02/28)
Compounds of formula (I) are disclosed, as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric diseases and disorders in a subject in need thereof are also disclosed.
Lewis acid-catalyzed tri- and difluoromethylation reactions of aldehydes
Mizuta, Satoshi,Shibata, Norio,Ogawa, Shinichi,Fujimoto, Hiroyuki,Nakamura, Shuichi,Toru, Takeshi
, p. 2575 - 2577 (2008/03/27)
The first Lewis acid-catalyzed trifluoromethylation reactions of aldehydes with Me3SiCF3 under TiF4/DMF, Ti(O iPr)4/DMF and Cu(OAc)2/dppp/toluene conditions are described. We have successfu
Facile preparation of difluoromethyl- and monofluoromethyl-containing amides via Ritter reaction
Liu, Jun,Ni, Chuanfa,Li, Ya,Zhang, Laijun,Wang, Guanyu,Hu, Jinbo
, p. 6753 - 6756 (2007/10/03)
Both secondary and tertiary difluoromethylated carbinols were found to readily react with acetonitrile under the catalysis of concentrated sulfuric acid to give the corresponding difluoromethylated acetamides in good yields, which is remarkably more effic
Nucleophilic difluoromethylation of carbonyl compounds using TMSCF 2SO2Ph and Mg0-mediated desulfonylation
Ni, Chuanfa,Hu, Jinbo
, p. 8273 - 8277 (2007/10/03)
A new nucleophilic difluoromethylation chemistry using fluoride-induced (phenylsulfonyl)difluoromethylation with TMSCF2SO2Ph followed by the magnesium-metal-mediated desulfonylation has been achieved. This methodology is compatible w
Nucleophilic difluoromethylation and difluoromethylenation using bromodifluoromethyl phenyl sulfone
Surya Prakash,Wang, Ying,Hu, Jinbo,Olah, George A.
, p. 1361 - 1367 (2007/10/03)
Tetrakis(dimethylamino)ethylene (TDAE) was found to be an effective electron-transfer agent that promoted the reactions of bromodifluoromethyl phenyl sulfone with aldehydes to give structurally diverse (benzenesulfonyl) difluoromethylated alcohols in good yield, which can be further transformed into difluoromethyl alcohols and 1,1-difluoro-1-alkenes via reductive desulfonylation and Julia olefination, respectively.
