117724-62-6

Basic information

• Product Name: ETHYL 4-(TRIFLUOROMETHYL)-2-METHYLTHIAZOLE-5-CARBOXYLATE
• Synonyms: ETHYL 2-METHYL-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE;ETHYL 2-METHYL-4-(TRIFLUOROMETHYL)-5-THIAZOLE CARBOXYLATE;ETHYL 2-METHYL-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLATE;ETHYL 4-(TRIFLUOROMETHYL)-2-METHYLTHIAZOLE-5-CARBOXYLATE;2-METHYL-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER;ethyl 4-(trifluoroMethyl)-2-Methylthiazol-5-carboxylate;5-Thiazolecarboxylic acid, 2-Methyl-4-(trifluoroMethyl)-, ethyl ester;2-Methyl-4-(trifluoromethyl)-5-thiazolecarboxylic acid ethyl ester
• CAS NO: 117724-62-6
• Molecular Formula: C₈H₈F₃NO₂S
• Molecular Weight: 239.21
• EINECS: 1312995-182-4
• Mol File: 117724-62-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: 34-37
• Boiling Point: 271.1 °C at 760 mmHg
• Flash Point: 117.8 °C
• Appearance: /
• Density: 1.356 g/cm³
• Vapor Pressure: 0.00657mmHg at 25°C
• Refractive Index: 1.467
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ETHYL 4-(TRIFLUOROMETHYL)-2-METHYLTHIAZOLE-5-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-(TRIFLUOROMETHYL)-2-METHYLTHIAZOLE-5-CARBOXYLATE(117724-62-6)
• EPA Substance Registry System: ETHYL 4-(TRIFLUOROMETHYL)-2-METHYLTHIAZOLE-5-CARBOXYLATE(117724-62-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 117724-62-6(Hazardous Substances Data)

Usage

General Description

Ethyl 4-(Trifluoromethyl)-2-methylthiazole-5-carboxylate is a complex organic chemical compound that belongs to the category of organofluorines and organosulfurs. It incorporates multiple functional groups, including a carboxylate ester, a thiazole ring, a trifluoromethyl group, as well as a methyl group. ETHYL 4-(TRIFLUOROMETHYL)-2-METHYLTHIAZOLE-5-CARBOXYLATE, like others with similar structures, may display a variety of chemical properties or may serve as a versatile building block in organic synthesis. Furthermore, its detailed properties, including its reactivity, stability, toxicity, and potential uses could potentially be determined through specialized testing and empirical analysis. However, exact use or function of this specific compound is not readily available without further specific context or data.

InChI:InChI=1/C8H8F3NO2S/c1-3-14-7(13)5-6(8(9,10)11)12-4(2)15-5/h3H2,1-2H3

Upstream product

• 4544-43-8 Ethyl 2-Bromo-4,4,4-trifluoro-3-oxobutanoate 
• 62-55-5 thioacetamide 
• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 
• 363-58-6 ethyl 2-chloro-4,4,4-trifluoro-3-oxobutanoate 

Downstream Products

• 117724-63-7 2-methyl-4-trifluoromethylthiazole-5-carboxylic acid 

Relevant articles and documents

Synthesis and biological activity of novel 2-methyl-4-trifluoromethyl-thiazole-5-carboxamide derivatives

Nine novel 2-methyl-4-trifluoromethylthiazole-5-carboxamide derivatives were designed and synthesized utilizing ethyl 4,4,4-trifluoroacetoacetate as a starting material. Subsequently, the biological activity of the compounds was evaluated in the greenhouse. Results indicated that all of the compounds have some fungicidal and insecticidal activity but no herbicidal activity. Compound 1 has fungicidal activity with 90% control of tomato late blight at 375 g ai/ha, while two compounds 2F and 2H show insecticidal activity with 80 and 100% control, respectively, against potato leafhopper at 600 g ai/ha.

2-methyl-4-(trifluoromethyl) thiazol-5-carboxylic acid

The invention discloses a method for preparing 2-methyl-4-(trifluoromethyl)thiazole-5-formyl acid. The method comprises the steps of synthesizing 2-bromo-trifluoro-ethyl acetoacetate and 2,2-dibromo-trifluoro-ethyl acetoacetate by reacting trifluoro ethyl acetoacetate with liquid bromine by using trifluoro ethyl acetoacetate as a raw material; then preparing ethyl acetoacetate of 2-methyl-4-(trifluoromethyl)thiazol-5-ethyl formate by reacting with an inert organic solvent solution of thioacetamide; and finally obtaining 2-methyl-4-(trifluoromethyl)thiazole-5-formyl acid by a hydrolysis reaction. The method has the advantages of novel raw materials and route, mild reaction conditions, simple operations, relatively high raw material conversion rate and product selectivity, convenient separation of target products, etc. The prepared 2-methyl-4-(trifluoromethyl)thiazole-5-formyl acid can be used for synthesizing a key intermediate of thiazole amide fungicides (thifluzamide).

Improved process for the preparation of thioacetamide

An improved process for the reaction of acetonitrile and hydrogen sulfide to produce thioacetamide, wherein a polymer-supported amine catalyst is used. Examples of the polymer-supported amine catalyst are polymeric dimethylaminopyridine resins, poly(4-vinylpyridine) cross-linked with divinylbenzene, and cross-linked polymer-supported 4-(N-benzyl-N-methylamino)pyridine.