1177248-64-4Relevant academic research and scientific papers
A Copper-Catalyzed Synthesis of Functionalized Quinazolines from Isocyanides and Aniline Tri- and Dichloroacetonitrile Adducts through Intramolecular C-H Activation
Nematpour, Manijeh,Rezaee, Elham,Tabatabai, Sayyed Abbas,Jahani, Mehdi
supporting information, p. 1441 - 1444 (2017/07/22)
A novel class of substituted quinazolines were prepared in good yields by a one-pot three-component reaction of isocyanides with adducts of anilines and tri- or dichloroacetonitrile, followed by intramolecular C-H activation, catalyzed by copper(I) iodide with l -proline as a ligand in acetonitrile at room temperature.
A new DMAP-catalyzed and microwave-assisted approach for introducing heteroarylamino substituents at position-4 of the quinazoline ring
Gellis, Armand,Kieffer, Charline,Primas, Nicolas,Lanzada, Gilles,Giorgi, Michel,Verhaeghe, Pierre,Vanelle, Patrice
, p. 8257 - 8266 (2015/03/03)
We report herein a new methodology for synthesizing quinazoline derivatives bearing a heteroarylamino moiety at position-4 of the quinazoline ring. As an alternative to the Buchwald-Hartwig cross-coupling reaction, which appears, until now, as the only efficient way to react 4-chloroquinazolines with numerous amino nitrogen-containing heterocycles displaying poor nucleophilicity, we developed a DMAP-catalyzed reaction involving microwave irradiation. Optimization of the reaction conditions led to the use of 30 mol % of DMAP in toluene, using a monomode microwave reactor and sealed vials. Moreover, the SNAr reaction intermediate salt was isolated and fully characterized. Finally, the procedure was extended to two different 2-substituted-quinazoline series and also to various anilines, demonstrating that this approach was a general efficient way to access to such 4-substituted quinazoline scaffolds of high pharmaceutical interest.
Synthesis and in vitro antiplasmodial evaluation of 4-anilino-2-trichloromethylquinazolines
Verhaeghe, Pierre,Azas, Nadine,Hutter, Sebastien,Castera-Ducros, Caroline,Laget, Michele,Dumetre, Aurelien,Gasquet, Monique,Reboul, Jean-Pierre,Rault, Sylvain,Rathelot, Pascal,Vanelle, Patrice
experimental part, p. 4313 - 4322 (2009/10/10)
To identify a new safe antiplasmodial molecular scaffold, an original series of 2-trichloromethylquinazolines, functionalized in position 4 by an alkyl- or arylamino substituent, was synthesized from 4-chloro-2-trichloromethylquinazoline 1, via a cheap, f
