1177266-41-9

Usage

Uses

Used in Pharmaceutical Industry:
2,7-Diazaspiro[4.4]nonane-2-carboxylic acid, 7-(phenylMethyl)-, 1,1-diMethylethyl ester is used as a potential pharmaceutical compound for its unique spiro structure and functional groups, which may contribute to the development of new drugs or therapeutic agents. Its specific application in this industry would require further research and testing to determine its properties and efficacy.
Used in Organic Synthesis:
In the field of organic synthesis, 2,7-Diazaspiro[4.4]nonane-2-carboxylic acid, 7-(phenylMethyl)-, 1,1-diMethylethyl ester serves as a building block for the creation of other complex organic molecules. Its unique structure and functional groups make it a valuable intermediate in the synthesis of various chemical entities, potentially leading to the discovery of new materials or compounds with specific applications.

Upstream product

• 885275-27-4 2-benzyl 2,7-diaza-spiro-[4.4]nonane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 2306252-57-1 2,7-diazaspiro[4.4]-nonane-2-carboxylic acid tert-butyl ester 
• 100-52-7 benzaldehyde 

Downstream Products

• 2306252-57-1 2,7-diazaspiro[4.4]-nonane-2-carboxylic acid tert-butyl ester 
• 1202177-91-0 (E)-(3,4-difluorophenyl){5-[(7-pyrazolo[1,5-b]pyridazin-3-yl-2,7-diazaspiro[4.4]non-2-yl)methyl]-2-pyridinyl}methanone O-ethyloxime 
• 1202179-14-3 1,1-Dimethylethyl 7-[(6-{[E)-(3,4-difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl]-2,7-diazaspiro[4.4]nonane-2-carboxylate 
• 1202179-20-1 (E)-[5-(2,7-diazaspiro[4.4]non-2-ylmethyl)-2-pyridinyl](3,4-difluorophenyl)methanone O-ethyloxime 
• 920531-65-3 2-benzyl-2,7-diazaspiro[4.4]nonane dihydrochloride 

Relevant academic research and scientific papers

ADAMANTANE DERIVATIVES FOR THE TREATMENT OF FILOVIRUS INFECTION

Compounds of structural Formula I were developed for the treatment of infections by filoviruses including Ebolavirus and Marburgvirus, wherein, R1, R2, R3, X and Y are defined in the specification.

ADAMATANE DERIVATIVES FOR THE TREATMENT OF FILOVIRUS INFECTION

Compounds of structural Formula (I) were developed for the treatment of infections by filoviruses including Ebolavirus and Marburgvirus.

SPIRODIAMINE-DIARYL KETOXIME DERIVATIVE

[Problem] To provide a melanin concentrating hormone receptor antagonist useful as medicines for central system disorders, cardiovascular disorders, metabolic disorders. [Means for Resolution] Provided are compound of a formula (I): [wherein R1 a and R1 b each are a hydrogen atom, etc.; R2 is a hydrogen atom, a C1-6 alkyl, etc.; Ar1 is a 6-membered aromatic carbocyclic group or a 6-membered aromatic nitrogen-containing heterocyclic group; Ar2 is a group to be formed by removing two hydrogen atoms from a 6-membered aromatic carbon ring, a 6-membered aromatic nitrogen-containing hetero ring, etc.; Ar3 is a mono- or bi-cyclic aromatic carbon ring or aromatic hetero ring; m1, m2, m3 and m4 each are independently 0, 1, 2, 3 or 4, provided that the total of m1 and m2 is from 2 to 6, the total of m3 and m4 is from 2 to 6]. The compounds are useful as medicines for central system disorders, cardiovascular disorders, metabolic disorders.

Preparation and characterization of N-(3-pyridinyl) spirocyclic diamines as ligands for nicotinic acetylcholine receptors

Several N-pyridin-3-yl spirobicyclic diamines, designed as conformationally restricted analogs of tebanicline (ABT-594), were synthesized as novel ligands for nicotinic acetylcholine receptors (nAChR). The spirocyclic compounds exhibited weaker binding affinity, than other constrained analogs in accord with a pharmacophore model. Nevertheless, some (1a, 1b) possessed (partial) agonist potencies comparable to nicotine at the α4β2 subtype, but with greatly improved selectivity relative to the α3β4* nAChR.