117738-76-8

Basic information

• Product Name: 4-Chloro-3-cyanobenzoic acid
• Synonyms: Benzoic acid, 4-chloro-3-cyano-
• CAS NO: 117738-76-8
• Molecular Formula: C₈H₄ClNO₂
• Molecular Weight: 181.57586
• Mol File: 117738-76-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 366.5±27.0 °C(Predicted)
• Appearance: /
• Density: 1.48±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.41±0.10(Predicted)
• CAS DataBase Reference: 4-Chloro-3-cyanobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-3-cyanobenzoic acid(117738-76-8)
• EPA Substance Registry System: 4-Chloro-3-cyanobenzoic acid(117738-76-8)

Safety Data

• Hazardous Substances Data: 117738-76-8(Hazardous Substances Data)

Usage

Uses

4-Chloro-3-cyanobenzoic Acid can be used as antiviral agents.

Upstream product

• 181282-80-4 methyl-3-Cyano-4-chloro-benzoate 
• 773837-37-9 sodium cyanide 
• 2840-28-0 3-amino-4-chloro-benzoic acid 
• 544-92-3 copper(I) cyanide 
• 151-50-8 potassium cyanide 

Downstream Products

• 1261751-27-2 ethyl 4-chloro-3-cyanobenzoate 
• 1444001-66-4 ethyl 4-chloro-3-(N'-hydroxycarbamimidoyl)benzoate 
• 1444001-67-5 ethyl 4-chloro-3-(N'-((ethoxycarbonyl)oxy)carbamimidoyl)benzoate 
• 1444001-65-3 ethyl 4-chloro-3-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoate 
• 1444001-68-6 4-chloro-3-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoic acid 
• 1444001-18-6 (S)-ethyl 1-(4-(5-((4-chloro-3-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzamido)methyl)-2-oxooxazolidin-3-yl)phenyl)piperidine-4-carboxylate 
• 1048033-36-8 N-[2-chloro-5-(1-{2-hydroxy-3-[4-(2-oxo-pyrrolidin-1-yl)-piperidin-1-yl]-propyl}-5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)-benzyl]-4-fluoro-benzamide 
• 1048034-29-2 1-(1-(3-[3-(4-chloro-3-phenylaminomethyl-phenyl)-5-methanesulfonyl-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propyl)-piperidin-4-yl)-pyrrolidin-2-one 
• 1048035-15-9 4-fluoro-benzoic acid 2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzyl ester 
• 1048690-57-8 C₂₁H₂₇ClN₄O₃S 
• 1048034-90-7 2-chloro-5-[1-(2-[1,3]dioxolan-2-yl-ethyl)-5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzonitrile 
• 1048035-05-7 C₁₇H₁₇ClN₄O₃S 
• 1048034-85-0 2-chloro-5-(5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)-benzylamine 
• 943732-47-6 tert-butyl 4-(4-chloro-3-cyanobenzoyl)piperazine-1-carboxylate 

Relevant articles and documents

PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES

Compounds of formula (I) as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.

CONDENSED PYRIMIDINE DERIVATIVE AND XANTHINE OXIDASE INHIBITOR

The invention relates to compounds of the following formula (I) or their salts: in which R 1 is a group of phenyl, naphthyl, pyridyl or the like which may have a substituent such as an alkyl group having 1-8 carbon atoms, an alkoxy group having 1-8 carbon atoms, an alkoxycarbonyl group having 2-8 carbon atoms, carboxyl, halogen, hydroxyl, nitro, or cyano; R 2 is cyano, nitro, or the like; R 3 is hydroxyl or the like; X is oxygen, sulfur, or the like; and Y is oxygen or sulfur, and a xanthine oxidase inhibitor containing the compound.

Structure-activity studies for a novel series of tricyclic substituted hexahydrobenz[e]isoindole α(1A) adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia (BPH)

In search of a uroselective agent that exhibits a high level of selectivity for the α(1A) receptor, a novel series of tricyclic hexahydrobenz[e]isoindoles was synthesized. A generic pharmacophoric model was developed requiring the presence of a basic amine core and a fused heterocyclic side chain separated by an alkyl chain. It was shown that the 6- OMe substitution with R, R stereochemistry of the ring junction of the benz[e]isoindole and a two-carbon spacer chain were optimal. In contrast to the highly specific requirements for the benz[e]isoindole portion and linker chain, a wide variety of tricyclic fused heterocyclic attachments were tolerated with retention of potency and selectivity. In vitro functional assays for the α1 adrenoceptor subtypes were used to further characterize these compounds, and in vivo models of vascular vs prostatic tone were used to assess uroselectivity.