2840-28-0

Usage

Uses

Used in Pharmaceutical Industry:
3-Amino-4-chlorobenzoic acid is used as a reagent for the preparation of novel bis-triazolyl-aryl-benzimidazole-thiol derivatives. These derivatives hold potential for various pharmaceutical applications, including the development of new drugs and therapeutic agents.
Used in Chemical Synthesis:
In the field of chemical synthesis, 3-Amino-4-chlorobenzoic acid serves as a key intermediate for the production of various organic compounds and specialty chemicals. Its unique structure allows for further functionalization and modification, making it a versatile building block in the synthesis of complex molecules.
Used in Research and Development:
3-Amino-4-chlorobenzoic acid is also utilized in research and development settings, where it can be employed to study the effects of structural modifications on the properties and reactivity of benzoic acid derivatives. This can lead to the discovery of new compounds with improved or novel properties for various applications.

Purification Methods

Crystallise the acid from water. [Beilstein 14 IV 1115.]

InChI:InChI=1/C7H6ClNO2/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3H,9H2,(H,10,11)/p-1

Upstream product

• 1843-35-2 3-azidobenzoic acid 
• 101870-46-6 3-(acetylamino)-4-chlorobenzoic acid 
• 96-99-1 4-chloro-3-nitrobenzoate 
• 7647-01-0 hydrogenchloride 
• 111-48-8 2,2'-thiobis-ethanol 
• 40872-87-5 methyl 3-amino-4-chlorobenzoate 

Downstream Products

• 99-05-8 meta-aminobenzoic acid 
• 101870-46-6 3-(acetylamino)-4-chlorobenzoic acid 
• 121490-68-4 quinoline-8-chloro-5-carboxylic acid 
• 74724-98-4 2-[(5-Carboxy-2-chloro-phenyl)-hydrazono]-heptanedioic acid 1-ethyl ester 
• 73177-33-0 2-Methyl-6-carboxyindole 
• 117738-76-8 3-Cyano-4-chloro-benzoic acid 
• 40872-87-5 methyl 3-amino-4-chlorobenzoate 
• 42860-04-8 4-chloro-3-iodobenzoic acid 
• 42860-10-6 3-bromo-4-chlorobenzoic acid 
• 91766-96-0 1-(3-amino-4-chlorobenzoyl)piperidine 
• 691362-86-4 methyl 2-oxobutanoate (5-carboxy-2-chlorophenyl)hydrazone 
• 475596-59-9 4-chloro-3-[3-(4-(5-phenylpentyloxy)phenyl)propanoylamino]benzoic acid 
• 6195-20-6 n-dodecyl 3-amino-4-chlorobenzoate 
• 143269-74-3 hexadecyl-3-amino-4-chlorobenzoate 

Relevant academic research and scientific papers

Platinum nanoparticles onto pegylated poly(lactic acid) stereocomplex for highly selective hydrogenation of aromatic nitrocompounds to anilines

A stereocomplexed poly(lactic acid)-polyethyleneglycol copolymer was synthesized and successfully used as recyclable support for Pt nanoparticles, generated by the metal vapor synthesis technique. The confinement of the Pt nanoparticles were determined by thermal analysis. Hydrogenation reactions of chlorinated aromatic nitro compounds, containing other reducible functional groups, to the corresponding anilines occurred with the latter supported Pt nanoparticles in MeOH under very mild reaction conditions (i.e. 30?°C, p(H2)?=?5.0?bar). The covalently attached polyethyleneglycol polymer significantly increased the catalytic activity of the supported Pt nanoparticles compared to an analogous catalytic system which did not contain polyethyleneglycol but the same sized Pt nanoparticles.

CARBOXYLIC ACID ARYL AMIDES

Compounds of formula and pharmaceutically acceptable salts thereof are described, as well as the pharmaceutical compositions containing said compounds and their pharmaceutically acceptable salts, and the use of said compounds and pharmaceutical compositions for the treatment, control or amelioration of proliferative diseases, including cancer.

A new class of heterogeneous platinum catalysts for the chemoselective hydrogenation of nitroarenes

A new series of nanostructured platinum catalysts able to catalyze the selective reduction of nitroarenes has been developed. The materials, made of organosilica physically doped with nanostructured platinum(0), are stable and efficient. Reactions in general proceed with high yield and often go to completion, while the catalysts can be reused in further reaction runs. This establishes a new class of relevant solid catalysts for synthetic organic chemistry named SiliaCat Platinum-Hydrogel.

3-(substituted phenyl)phthalides

Process comprises the combination of the three steps of condensing 3-N(R)2 -4-X-benzoic acid with an aromatic or heterocyclic aldehyde, Y-CHO, under acidic conditions to produce 3-Y-5-X-6-N(R)2 phthalide (II), condensing said phthalide with a compound of the formula Z-H under alkaline or acid conditions to produce 2-(α-Y-α-Z)methyl-4-X-5-N(R)2 benzoic acid (III), and oxidizing said benzoic acid to produce 3-Y-3-Z-5-X-6-N(R)2 phthalide (I) where: R is hydrogen, non-tertiary alkyl of one to four carbon atoms, benzyl or substituted benzyl; X is hydrogen or halo; Y is 4-R1 -3-R2 -2-R1 -phenyl, 1-R5 -2-R6 -5/6-R4 -3-indolyl, 9-R7 -3-carbazolyl, 9-julolidinyl, 3,4-dioxymethylenephenyl, 2-thienyl, 1-R8 -2-pyrrolyl, or 4-pyridinyl; and Z is 4-R1 -3-R2 -2-R1 -phenyl, 1-R5 -2-R6 -5/6-R4 -3-indolyl or 1-R8 -2-pyrrolyl which are useful as colorless precursor color formers in carbonless duplicating and in thermal marking systems. The intermediates, 3-Y-5-X-6-N(R)2 phthalides (II) and 2-(α-Y-α-Z)methyl-4-X-5-N(R)2 benzoic acids (III) also have utility as colorless precursor color formers in carbonless duplicating and thermal marking systems.

Chlorinated aromatic amines

An improvement in a process for the preparation of chlorinated aromatic amines by hydrogenation of the corresponding chlorinated nitro-aromatic compounds in the presence of a noble metal catalyst on a carbon support and in the presence of a sulfur compound, the improvement residing in that the sulfur compound is a thio-ether. Preferably the reaction is carried out in a weakly basic medium.

One step diazotization coupling process

A process for producing metal-free azo pigments in purely organic liquid or aqueous/organic liquid containing at most 10% of water calculated on the total weight of the suspension is described. In this one-step process, a suitable aromatic amine is diazotized without isolation of the obtained diazo compound and coupled with a coupling component. Both reactions are carried out in purely or essentially organic medium. The latter consists essentially of such amount of an organic liquid that a substantial portion either of the diazo component or of the coupling component or of both these reactants remain undissolved. Both reactants must be free from sulphonic acid groups. If the resulting azo pigment contains carboxylic acid groups, these can be subsequently converted to the corresponding amido or ester groups.