1177445-13-4

Upstream product

• 402-50-6 1-trifluoromethyl-4-vinyl-benzene 
• 35660-91-4 (E)-1-phenyl-2-buten-1-one 
• 855249-36-4 (E,Z)-1-(buta-1,3-dien-1-yl)-4-(trifluoromethyl)benzene 
• 98-86-2 acetophenone 

Relevant academic research and scientific papers

Nickel(0)-Catalyzed Hydroalkylation of 1,3-Dienes with Simple Ketones

We developed a highly regioselective addition of 1,3-dienes with simple ketones by nickel-hydride catalyst bearing DTBM-SegPhos ligand. A wide range of aromatic and aliphatic ketones directly coupled with 1,3-dienes, providing synthetically useful γ,δ-unsaturated ketones in high yield and regioselectivity. The asymmetric version of the reaction was also realized in high enantioselectivity by using novel chiral ligand DTBM-HO-BIPHEP. The utility of this hydroalkylation was demonstrated by facile product modification and enantioselective synthesis of (R)-flobufen.

Nickel-catalyzed direct conjugate addition of simple alkenes to enones

(Chemical Equation Presented) A direct conjugate addition of simple alkenes to enones has been achieved in the presence of a Ni(0)/PCy3 catalyst.