117858-83-0

Basic information

• Product Name: N-benzyl-1,4-dideoxy-2,3:5,6-di-O-isopropylidene-1,4-imino-D-allitol
• Synonyms: N-benzyl-1,4-dideoxy-2,3:5,6-di-O-isopropylidene-1,4-imino-D-allitol
• CAS NO: 117858-83-0
• Molecular Weight: 333.428
• Mol File: 117858-83-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-benzyl-1,4-dideoxy-2,3:5,6-di-O-isopropylidene-1,4-imino-D-allitol(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-1,4-dideoxy-2,3:5,6-di-O-isopropylidene-1,4-imino-D-allitol(117858-83-0)
• EPA Substance Registry System: N-benzyl-1,4-dideoxy-2,3:5,6-di-O-isopropylidene-1,4-imino-D-allitol(117858-83-0)

Safety Data

• Hazardous Substances Data: 117858-83-0(Hazardous Substances Data)

Upstream product

• 29474-78-0 D-allono-1,4-lactone 
• 27108-15-2 2,3:5,6-di-O-isopropylidene-D-allono-1,4-lactone 
• 73209-94-6 (1R)-(2,2-dimethyl-1,3-dioxolan-4-yl)-((4R,5S)-5-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methanol 
• 100-46-9 benzylamine 
• 4306-35-8 1,2-mono-O-isopropylidene-D-mannitol 
• 67642-42-6 2,3,5,6-di-O-isopropylidene-D-gulono-1,4-lactone 
• 6322-07-2 D-gulono-1,4-lactone 
• 3969-61-7 2,3:5,6-di-O-isopropylidene-D-gulitol 
• 117859-45-7 methanesulfonic acid (S)-((4R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-((4S,5S)-5-methanesulfonyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-methyl ester 

Downstream Products

• 117858-84-1 N-benzyl-1,4-dideoxy-1,4-imino-2,3-O-isopropylidene-D-ribitol 
• 117770-18-0 N-benzyl-1,4-dideoxy-1,4-imino-D-ribitol 
• 95341-64-3 (2S,3R,4S)-3,4-dihydroxypyrrolidine-2-carboxylic acid 
• 117859-47-9 N-benzyl-1,4-dideoxy-5,6-O-isopropylidene-1,4-imino-D-allitol 
• 117770-11-3 N-benzyl-1,4-dideoxy-1,4-imino-D-allitol 

Relevant articles and documents

Novel 2-[(benzylamino)methyl]pyrrolidine-3,4-diol derivatives as α-mannosidase inhibitors and with antitumor activities against hematological and solid malignancies

Novel α-mannosidase inhibitors of the type (2R,3R,4S)-2-({[(1R)-2-hydroxy-1-arylethyl]amino}methyl)pyrrolidine-3,4-diol have been prepared and assayed for their anticancer activities. Compound 30 with the aryl group = 4-trifluoromethylbiphenyl inhibits the proliferation of primary cells and cell lines of different origins, irrespective of Bcl-2 expression levels, inducing a G2/Mcell cycle arrest and by modification of genes involved in cell cycle progression and survival.

Derivatives of Dihydroxypyrrolidine as Anti-Cancer Compounds

The present invention relates to derivatives of dihydroxypyrrolidine useful in the treatment of cancer. The invention further relates to a process for making the compounds. The compounds are inhibitors of α mannosidase, and possibly, also inhibit nicotina