117872-44-3

Upstream product

• 117856-42-5 1,4-dibenzyl-3-<3'-(diphenyl-t-butylsilyloxy)propyl>piperazine-2,5-dione 
• 42492-87-5 N,N'-dibenzylpiperazine-2,5-dione 
• 1040726-58-6 1,4-dibenzyl-3-(3-acetoxypropyl)piperazine-2,5-dione 
• 1040726-54-2 4-benzylcarbamoyl-4-[benzyl-(2-chloroacetyl)amino]butyl acetate 
• 110-63-4 Butane-1,4-diol 
• 88333-03-3 Benzyl isocyanide 
• 79-11-8 chloroacetic acid 
• 100-46-9 benzylamine 

Downstream Products

• 83135-85-7 8,10-dibenzyl-2-oxa-8,10-diazabicyclo<4.2.2>decane-7,9-dione 
• 117856-43-6 1,4-dibenzyl-3-(3'-bromopropyl)piperazine-2,5-dione 

Relevant academic research and scientific papers

Studies towards the synthesis of bicyclomycin precursors: Synthesis of N,N′-disubstituted 2,5-diketopiperazines in solution and on solid phase

(Chemical Equation Presented) The synthesis of 3-(hydroxyalkyl)-N,N′- disubstituted 2,5-diketopiperazine derivatives - compounds required for the bicyclomycin analogues preparation - has been studied. The use of various oxo components in the Ugi multicomp

Synthetic Studies on Bicyclomycin and its Analogues. Part 1. Synthesis of Substituted 2-Oxa-8,10-diazabicyclodecanes

Methods have been developed for formation of the eight-membered oxygen-containing ring system (2) present in the antibiotic bicyclomycin.The procedure starts with N,N'-disubstituted piperazine-2,5-diones or the corresponding mono imino ethers.A new method is based on the oxidation of the mono imino ethers using 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) as oxidant: the bis imino ethers gave pyrazines under these conditions, whilst the parent piperazinedione proved to be unreactive.