83135-85-7

Upstream product

• 117856-42-5 1,4-dibenzyl-3-<3'-(diphenyl-t-butylsilyloxy)propyl>piperazine-2,5-dione 
• 42492-87-5 N,N'-dibenzylpiperazine-2,5-dione 
• 91238-09-4 8,10-bis(p-methoxybenzyl)-8,10-diaza-2-oxabicyclo<4.2.2>decane-7,9-dione 
• 117872-44-3 1,4-dibenzyl-3-(3'-hydroxypropyl)piperazine-2,5-dione 
• 100-39-0 benzyl bromide 
• 95999-85-2 8,10-diaza-2-oxabicyclo<4.2.2>decane-7,9-dione 

Downstream Products

• 96000-01-0 8,10-dibenzyl-8,10-diaza-6-hydroxy-1-<2'-methyl-1'-hydroxy-2',3'-(isopropylidenedioxy)propyl>-2-oxabicyclo<4.2.2>decane-7,9-dione 
• 96000-01-0 8,10-dibenzyl-8,10-diaza-6-hydroxy-1-<2'-methyl-1'-hydroxy-2',3'-(isopropylidenedioxy)propyl>-2-oxabicyclo<4.2.2>decane-7,9-dione 
• 95999-87-4 8,10-dibenzyl-8,10-diaza-6-hydroxy-2-oxabicyclo<4.2.2>decane-7,9-dione 
• 96548-12-8 (1R,6S)-7,9-Dibenzyl-6-hydroperoxy-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione 

Relevant academic research and scientific papers

Synthetic Studies on Bicyclomycin and its Analogues. Part 1. Synthesis of Substituted 2-Oxa-8,10-diazabicyclodecanes

Methods have been developed for formation of the eight-membered oxygen-containing ring system (2) present in the antibiotic bicyclomycin.The procedure starts with N,N'-disubstituted piperazine-2,5-diones or the corresponding mono imino ethers.A new method is based on the oxidation of the mono imino ethers using 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) as oxidant: the bis imino ethers gave pyrazines under these conditions, whilst the parent piperazinedione proved to be unreactive.

Synthesis and antimicrobial evaluation of bicyclomycin analogues

The synthesis and antimicrobial evaluation of novel bicyclomycin analogues are described. The series of analogues were prepared from the basic 8,10-diaza-2-oxabicyclo[4.2.2]decane-7,9-dione (8), 7,9-diaza-2-oxabicyclo[3.2.2]nonane-6,8-dione (9), 8,10-diaz