117947-05-4

Usage

Chemical Structure

It is a derivative of phenoxyacetic acid.
Contains a bromine atom and a tert-butyl group.

Function

Used as a herbicide and plant growth regulator.

Mode of Action

Disrupts plant growth hormones.
Induces abnormal growth leading to plant death.

Selective Herbicide

Targets specific types of plants while sparing others.

Safety Considerations

Potential toxicity and environmental impact.
Usage should adhere to safety guidelines and regulations.

Upstream product

• 105-36-2 ethyl bromoacetate 
• 1435933-50-8 C₁₆H₂₃BrO₃ 
• 2198-66-5 2-bromo-4-tert-butylphenol 
• 953091-05-9 (2-bromo-4-tert-butyl-phenoxy)-acetic acid ethyl ester 

Downstream Products

• 1435933-41-7 C₂₀H₂₆BrN₃O₃ 

Relevant academic research and scientific papers

Discovery of potent transient receptor potential vanilloid 1 antagonists: Design and synthesis of phenoxyacetamide derivatives

We aimed to discover a novel type of transient receptor potential vanilloid 1 (TRPV1) antagonist because such antagonists are possible drug candidates for treating various disorders. We modified the structure of hit compound 7 (human TRPV1 IC50 = 411 nM) and converted its pyrrolidino group to a (hydroxyethyl)methylamino group, which substantially improved inhibitory activity (15d; human TRPV1 IC50 = 33 nM). In addition, 15d ameliorated bladder overactivity in rats in vivo.

NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1) antagonist; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, inflammatory disease of the joints, neuropathies, HIV-related neuropathy, nerve injury, neurodegeneration, stroke, urinary bladder hypersensitivity including urinary incontinence, cystitis, stomach duodenal ulcer, irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), fecal urgency, gastro-esophageal reflux disease (GERD), Crohn's disease, asthma, chronic obstructive pulmonary disease, cough, neurotic/allergic/inflammatory skin disease, psoriasis, pruritus, prurigo, irritation of skin, eye or mucous membrane, hyperacusis, tinnitus, vestibular hypersensitivity, episodic vertigo, cardiac diseases such as myocardial ischemia, hair growth-related disorders such as effluvium, alopecia, rhinitis, and pancreatitis.