1179810-87-7

Upstream product

• 3088-79-7 n-dodecylboronic acid 
• 1179811-00-7 1-(3-bromophenyl)-1-hydroxy-1,2-dihydropyrrolo[3,4-c]pyridine-3-one 
• 1179811-05-2 4-(3-bromobenzoyl)nicotinic acid 
• 1247691-67-3 4-((3-bromophenyl)(hydroxy)methyl)-N,N-diisopropyl nicotinamide 
• 1179811-02-9 4-(3-bromobenzoyl)-N,N-diisopropylnicotinamide 
• 207681-67-2 N-methoxy-N-methyl-3-bromobenzamide 
• 585-76-2 m-bromobenzoic acid 

Downstream Products

• 1179810-89-9 1-(3-dodecylphenyl)-5-[2-(ethyloxy)-2-oxoethyl]-1-hydroxy-3-oxo-1,2-dihydropyrrolo[3,4-c]pyridinium bromide 
• 1180022-76-7 1-(3-dodecylphenyl)-5-[2-(ethyloxy)-2-oxoethyl]-1-hydroxy-3-oxo-1,2-dihydropyrrolo[3,4-c]pyridinium 
• 1179810-90-2 C₂₉H₄₂N₂O₄ 

Relevant academic research and scientific papers

NOVEL ANTI-INFECTIOUS DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USES OF SAID DERIVATIVES IN TREATMENT

The invention relates to bi-substrate inhibitor molecules associating (i) a pyridine, pyridinium or dihydropyridine-type structure allied to active metabolites of isoniazide, or related structures, and (ii) a hydrophobic substituent. The invention also re

Development of isoniazid-NAD truncated adducts embedding a lipophilic fragment as potential bi-substrate InhA inhibitors and antimycobacterial agents

Isoniazid-NAD truncated adducts embedding a lipophilic fragment were designed, synthesized and evaluated as inhibitors of the enoyl-acyl carrier protein (ACP) reductase (InhA) of Mycobacterium tuberculosis and as antimycobacterial agents. These compounds, planned as bi-substrate inhibitors and inspired from the active metabolite of isoniazid, combine both the nicotinamide moiety of the cofactor NAD and a lipophilic hydrocarbon chain mimic of the InhA substrate. The lipophilic fragment was introduced using either Suzuki-Miyaura cross-coupling or a classical nucleophilic substitution reaction. Several compounds developed in this work were indeed able to inhibit the InhA activity and showed promising antimycobacterial activities. However a direct correlation between the expressed activity and the bi-substrate mode of action could not yet be unambiguously demonstrated.