1179998-29-8

Usage

Chemical Properties

Colourless Solid

Uses

Protected Daidzein

Upstream product

• 486-66-8 daidzein 
• 100-39-0 benzyl bromide 
• 17720-60-4 2,4,4'-trihydroxy deoxybenzoin 
• 156-38-7 4-hydroxyphenylacetate 
• 108-46-3 recorcinol 

Downstream Products

• 1233943-92-4 1-{4-[4-(benzyloxy)-2-hydroxyphenyl]-5-[4-(benzyloxy)phenyl]pyrimidin-2-yl}thiourea 
• 81267-65-4 idronoxil 
• 1456626-77-9 3-cyano-6-(4-benzyloxy-2-hydroxyphenyl)-5-(4-benzyloxyphenyl)pyridin-2(1H)-one 
• 1427272-74-9 3-cyano-6-(4-benzyloxy-2-hydroxylphenyl)-5-(4-benzyloxyphenyl)-pyridine-2(1H)-thione 
• 1365659-35-3 3-cyano-6-(4-benzyloxyphenyl)-7-(2-hydroxyl-4-benzyloxyphenyl)pyrazolo[1,5-a]pyrimidine 
• 1179998-17-4 2-(2-hydroxy-4-benzyloxyphenyl)-3-(4-benzyloxyphenyl)-pyrimido[1,2-a]benzimidazole 

Relevant academic research and scientific papers

Structure–activity relationship of phytoestrogen analogs as ERα/β agonists with neuroprotective activities

A set of isoflavononid and flavonoid analogs was prepared and evaluated for estrogen receptor α (ERα) and ERβ transactivation and anti-neuroinflammatory activities. Structure–activity relationship (SAR) study of naturally occurring phytoestrogens, their metabolites, and related isoflavone analogs revealed the importance of the C-ring of isoflavonoids for ER activity and selectivity. Docking study suggested putative binding modes of daidzein 2 and dehydroequol 8 in the active site of ERα and ERβ, and provided an understanding of the promising activity and selectivity of dehydroequol 8. Among the tested compounds, equol 7 and dehydroequol 8 were the most potent ERα/β agonists with ERβ selectivity and neuroprotective activity. This study provides knowledge on the SAR of isoflavonoids for further development of potent and selective ER agonists with neuroprotective potential.