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Acetyl-epipodophyllotoxin is a semi-synthetic derivative of podophyllotoxin, a plant compound with anti-tumor properties. It is a promising anti-cancer drug candidate that has demonstrated effectiveness in treating various types of cancer, such as lung, breast, and colorectal cancer. Acetylepipodophyllotoxin works by inhibiting the growth of cancer cells, inducing apoptosis, and disrupting the formation of microtubules, which are essential for cell division. Acetyl-epipodophyllotoxin also exhibits lower toxicity and better solubility compared to the natural podophyllotoxin, making it a favorable option for further development in cancer therapy.

1180-35-4

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1180-35-4 Usage

Uses

Used in Pharmaceutical Industry:
Acetyl-epipodophyllotoxin is used as an anti-cancer agent for its ability to inhibit the growth of cancer cells and induce apoptosis. It is particularly effective against lung, breast, and colorectal cancers due to its mechanism of action in disrupting microtubule formation, which is crucial for cell division.
Used in Cancer Treatment:
Acetyl-epipodophyllotoxin is used as a therapeutic agent for the treatment of various types of cancer. Its lower toxicity and better solubility compared to the natural podophyllotoxin make it a promising candidate for further development and potential incorporation into cancer treatment regimens.
Used in Drug Development:
Acetyl-epipodophyllotoxin is used as a starting material for the development of new anti-cancer drugs. Its unique properties and effectiveness in inhibiting cancer cell growth and inducing apoptosis make it a valuable compound for the creation of novel cancer therapies.
Used in Research:
Acetyl-epipodophyllotoxin is used as a research tool to study the mechanisms of cancer cell growth inhibition and apoptosis induction. Its role in disrupting microtubule formation provides valuable insights into the development of new cancer treatment strategies and the understanding of the cellular processes involved in tumor growth and progression.

Check Digit Verification of cas no

The CAS Registry Mumber 1180-35-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,8 and 0 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1180-35:
(6*1)+(5*1)+(4*8)+(3*0)+(2*3)+(1*5)=54
54 % 10 = 4
So 1180-35-4 is a valid CAS Registry Number.

1180-35-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name (5S,5aR,8aR,9R)-8-Oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-he xahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl acetate

1.2 Other means of identification

Product number -
Other names acetylenemagnesium bromide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1180-35-4 SDS

1180-35-4Relevant academic research and scientific papers

Stereoselective synthesis of 4β-acyloxypodophyllotoxin derivatives as insecticidal agents

Che, Zhi-Ping,Tian, Yue-E,Liu, Sheng-Ming,Jiang, Jia,Hu, Mei,Chen, Gen-Qiang

, p. 1028 - 1041 (2018/07/15)

As our ongoing work on research of natural-product-based insecticidal agents, some 4α/β-acyloxypodophyllotoxin derivatives were synthesized, and were evaluated against the pre-third-instar larvae of B. mori, A. dissimilis and M. separate in vivo at the co

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