118001-69-7

Basic information

• Product Name: 2-(4-IODOPHENYL)IMIDAZO[1,2-A]PYRIMIDINE
• Synonyms: 2-(4-IODOPHENYL)IMIDAZO[1,2-A]PYRIMIDINE
• CAS NO: 118001-69-7
• Molecular Formula: C₁₂H₈IN₃
• Molecular Weight: 321.12
• Mol File: 118001-69-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-IODOPHENYL)IMIDAZO[1,2-A]PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-IODOPHENYL)IMIDAZO[1,2-A]PYRIMIDINE(118001-69-7)
• EPA Substance Registry System: 2-(4-IODOPHENYL)IMIDAZO[1,2-A]PYRIMIDINE(118001-69-7)

Safety Data

• Hazardous Substances Data: 118001-69-7(Hazardous Substances Data)

Usage

Type of compound

Heterocyclic compound

Structure

Contains an imidazo[1,2-a]pyrimidine ring system with a 4-iodophenyl group attached at the 2-position

Pharmacological properties

Acts as a kinase inhibitor

Potential uses

Cancer treatment, therapeutic agent for various diseases

Other potential uses

Organic synthesis, building block for the preparation of other compounds

Upstream product

• 109-12-6 2-aminopyrimidine 
• 31827-94-8 2-bromo-1-(4-iodophenyl)ethanone 
• 13329-40-3 4-Iodoacetophenone 

Downstream Products

• 118001-70-0 4-imidazo[1,2-a]pyrimidin-2-ylbenzaldehyde 
• 1259389-22-4 2-(4-(4-butyl-1H-1,2,3-triazol-1-yl)phenyl)-3-p-tolylimidazo-[1,2-a]pyrimidine 
• 1259389-26-8 3-benzyl-2-(4-(4-butyl-1H-1,2,3-triazol-1-yl)phenyl)imidazo-[1,2-a]pyrimidine 
• 1259389-18-8 2-(4-(4-butyl-1H-1,2,3-triazole)phenyl)imidazo[1,2-a]-pyrimidine 
• 104691-51-2 2-(4-Cyano-phenyl)-imidazo[1,2-a]pyrimidine 

Relevant articles and documents

Predictable and site-selective functionalization of poly(hetero)arene compounds by palladium catalysis

The challenge of achieving selective and predictable functionalizations at C-H bonds with complex poly(hetero)aromatic substrates was addressed by two different approaches. Site-selectivity can be obtained by applying various reaction conditions that are (hetero)arene specific to substrates that contain indoles, pyridine N-oxide, and polyfluorinated benzenes. An experimental classification of electron-rich heteroarenes based on their reactivity toward palladium-catalyzed C-Hfunctionalization was established, the result of which correlated well with the order of reactivity predicted by the DFT-calculated concerted metalation-deprotonation (CMD) pathway. Model substrates containing two reactive heteroarenes were then reacted under general reaction conditions to demonstrate the applicability this reactivity chart in predicting the regioselectivity of the palladium-catalyzed direct arylation and benzylation reactions.