209860-89-9Relevant academic research and scientific papers
Preparation method of high-purity Tafluprost and analogs thereof and intermediate compound
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Paragraph 0042-0043, (2017/10/13)
The invention belongs to the technical field of medicine, and relates to a preparation method of Tafluprost and analogs thereof and a related intermediate compound. The preparation method is characterized in that (4-carboxybutyl)triphenylphosphonium bromide having a structure shown below is used as a witting reaction reagent, wherein R is alkyl or aryl. The method is simple, feasible and convenient for industrial production; and the Tafluprost and analogs thereof which are basically free of omega chain trans-isomers can be prepared.
