1180491-75-1

Upstream product

• 1180491-77-3 methyl 3-(2-(3,5-dimethoxyphenyl)-2-oxoethoxy)-5-methoxybenzoate 
• 50841-50-4 (2-bromo-1-(3,5-dimethoxyphenyl)ethanone) 
• 19520-74-2 3-hydroxy-5-methoxy-benzoic acid methyl ester 
• 39151-19-4 1-(3,5-dimethoxyphenyl)ethan-1-one 
• 2150-44-9 1-carbomethoxy-3,5-dihydroxybenzene 
• 99-10-5 3,5-Dihydroxybenzoic acid 

Downstream Products

• 1180491-79-5 methyl 3-(3,5-dimethoxyphenyl)-6-methoxy-2-(4-nitrophenyl)benzofuran-4-carboxylate 
• 1180491-78-4 dimethyl 3,3'-bis(3,5-dimethoxyphenyl)-6,6'-dimethoxy-2,2'-bibenzofuran-4,4'-dicarboxylate 
• 1180491-74-0 methyl 3-(3,5-dimethoxyphenyl)-6-methoxy-2-(4-methoxyphenyl)-benzofuran-4-carboxylate 
• 1180491-83-1 methyl 3-(3,5-dimethoxyphenyl)-2-(4-(ethoxycarbonyl)phenyl)-6-methoxybenzofuran-4-carboxylate 
• 1180491-82-0 methyl 2-(4-cyanophenyl)-3-(3,5-dimethoxyphenyl)-6-methoxybenzofuran-4-carboxylate 
• 1180491-81-9 methyl 3-(3,5-dimethoxyphenyl)-6-methoxy-2-(4-trifluoromethylphenyl)benzofuran-4-carboxylate 
• 1180491-80-8 methyl 3-(3,5-dimethoxyphenyl)-2-(4-fluorophenyl)-6-methoxybenzofuran-4-carboxylate 
• 1180491-86-4 3-(3,5-dimethoxyphenyl)-(6-methoxy-2-(4-methoxyphenyl)-benzofuran-4-yl) methanol 

Relevant academic research and scientific papers

Total synthesis of the resveratrol oligomers (±)-Ampelopsin B and (±)-σ-Viniferin

The total synthesis of the resveratrol dimers (±)-ampelopsin B and (±)-σ-viniferin is reported. Highlights of the approach include the use of cyclopropylmethyl groups to protect aromatic alcohols. This group allows an acid promoted three-step, one-pot dep

Orally Administered Benzofuran Derivative Disaggregated Aβ Plaques and Oligomers in the Brain of 5XFAD Alzheimer Transgenic Mouse

Amyloid-β (Aβ) aggregated forms are highly associated with the onset of Alzheimer's disease (AD). Aβ abnormally accumulates in the brain and induces neuronal damages and symptoms of AD such as cognitive impairment and memory loss. Since an antibody drug,

A facile and practical total synthetic route for ampelopsin F and permethylated ?-viniferin

Stilbene dimers (±)-ampelospin F and permethylated (±)-?-viniferin were synthesized by a practical synthetic route with overall yields of 10% and 27%. This route involves triethylsilane-mediated reduction of the 2,3-diarylbenzofuran, and BBr3-mediated one-pot demethylation and cascade intramolecular cyclization reaction.

Total Synthesis of Viniferifuran, Resveratrol-Piceatannol Hybrid, Anigopreissin A and Analogues – Investigation of Demethylation Strategies

Resveratrol-based natural products constitute a valuable source of unique compounds with diverse biological activities. In this report we investigate demethylation strategies to minimize formation of cyclized and dimerized products during the synthesis of viniferifuran and analogues. We found that boron trichloride/tetra-n-butylammonium iodide (BCl3/TBAI) is typically more effective than boron tribromide (BBr3). Based on these findings we carried out the first syntheses of dehydro-δ-viniferin, resveratrol-piceatannol hybrid and anigopreissin A. In addition, we have developed a short and efficient route to viniferifuran that was obtained in 13% yield over six steps. (Figure presented.).

A versatile approach to oligostilbenoid natural products - Synthesis of permethylated analogues of viniferifuran, malibatol A, and shoreaphenol

A highly practical route to oligostilbenoid natural products is described. A regioselective Bi(OTf)3-catalyzed cyclodehydration provided ready access to 3-arylbenzofuran. Pd-catalyzed direct C-H activation of benzofuran and subsequent cross-cou