118097-24-8

Basic information

• Product Name: 4-(4-bromobenzoyl)-5-methyl-1H-imidazol-2(3H)-one
• Synonyms: 4-(4-bromobenzoyl)-5-methyl-1H-imidazol-2(3H)-one
• CAS NO: 118097-24-8
• Molecular Weight: 281.109
• Mol File: 118097-24-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-bromobenzoyl)-5-methyl-1H-imidazol-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-bromobenzoyl)-5-methyl-1H-imidazol-2(3H)-one(118097-24-8)
• EPA Substance Registry System: 4-(4-bromobenzoyl)-5-methyl-1H-imidazol-2(3H)-one(118097-24-8)

Safety Data

• Hazardous Substances Data: 118097-24-8(Hazardous Substances Data)

Upstream product

• 1488363-22-9 (Z)-3-amino-1-(4-bromophenyl)but-2-en-1-one 
• 99-90-1 para-bromoacetophenone 

Relevant articles and documents

A simple synthesis of 4-aroyl-5-methyl-1H-imidazol-2(3H)-one derivatives (Enoxymone analogues) from aryl methyl ketones via enaminones

Aryl methyl ketones 1a-e gave with N,N-dimethylacetamide dimethylacetal (DMADMA) (E)-1- aryl-3-(dimethylamino)-but-2-en-1-ones 2a-e. Substitution of the N,N-(dimethylamino) group in the reaction with ammonium acetate afforded the corresponding (Z)-3-amino-1-aryl-but-2-en-1- ones 3a-e. In the reaction of 3a-e with diethyl azodicarboxylate intermediates 4a-e were formed, which were, in most cases without isolation, cyclized into ethyl (5-aroyl-4-methyl-2-oxo-2,3- dihydro-1H-imidazol-1-yl)carbamates 5a-e. Hydrolysis of the ester group, followed by the decarboxylation and deamination of intermediates 6a-c,e produced 4-aroyl-5-methyl-1Himidazol- 2(3H)-ones 7a-c,e.