1181809-22-2

Upstream product

• 29632-74-4 2-fluro-4-iodoaniline 
• 137520-86-6 2,6-dichloro-5-methylnicotinic acid ethyl ester 
• 1181809-27-7 5-chloro-3-(2-fluoro-4-iodo-phenylamino)-6-methyl-[1,4]oxazin-2-one 
• 623-47-2 propynoic acid ethyl ester 

Downstream Products

• 1181809-34-6 2-chloro-6-(2-fluoro-4-iodo-phenylamino)-5-ethoxycarbonyl-1,3-dimethyl-pyridinium trifluoromethanesulfonate 

Relevant academic research and scientific papers

Heterocyclic compound as protein kinase inhibitor and preparation method and application thereof

The invention relates to a compound of formulas (I) and (II) and a pharmaceutically acceptable salt, prodrug and solvate thereof, wherein R1, R2, R3, A and X are as defined in the specification. The compound is a protein kinase inhibitor, particularly the protein kinase inhibitor Mek inhibitor, and can be used for treating cancers and inflammation in mammals. The invention further discloses a preparation method of the compound of formulas (I) and (II) and a medicine composition containing the compound.

PROCESS FOR PREPARING PYRIDONE DERIVATIVES 226

A route for preparing a compound of formula (I), where X, R1,R2, R7, R8 and R9 are as defined in the specification, is described. Process steps used in the route and novel intermediates prepared during the route are also described and claimed. Compounds of formula (I) are used in the preparation of pharmaceutical compounds, in particular inhibitors of MEK, useful in the treatment of hyperproliferative disease such as cancer and inflammatory conditions.