6-chloro-2-(2-fluoro-4-iodophenylamino)-5-methylnicotinic acid ethyl ester

Base Information

Chemical Name:6-chloro-2-(2-fluoro-4-iodophenylamino)-5-methylnicotinic acid ethyl ester
CAS No.:1181809-22-2
Molecular Formula:C₁₅H₁₃ClFIN₂O₂
Molecular Weight:434.636
Hs Code.:

Synonyms:6-chloro-2-(2-fluoro-4-iodophenylamino)-5-methylnicotinic acid ethyl ester

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Chemical Property of 6-chloro-2-(2-fluoro-4-iodophenylamino)-5-methylnicotinic acid ethyl ester

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Technology Process of 6-chloro-2-(2-fluoro-4-iodophenylamino)-5-methylnicotinic acid ethyl ester

There total 2 articles about 6-chloro-2-(2-fluoro-4-iodophenylamino)-5-methylnicotinic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1181809-27-7
5-chloro-3-(2-fluoro-4-iodo-phenylamino)-6-methyl-[1,4]oxazin-2-one

: 623-47-2
propynoic acid ethyl ester

: 1181809-22-2
6-chloro-2-(2-fluoro-4-iodophenylamino)-5-methylnicotinic acid ethyl ester

Guidance literature:: In acetic acid butyl ester; at 120 ℃; Product distribution / selectivity;

Reference yield: 81.0%

: 29632-74-4
2-fluro-4-iodoaniline

: 137520-86-6
2,6-dichloro-5-methylnicotinic acid ethyl ester

: 1181809-22-2
6-chloro-2-(2-fluoro-4-iodophenylamino)-5-methylnicotinic acid ethyl ester

Guidance literature:: 2-fluro-4-iodoaniline; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

2,6-dichloro-5-methylnicotinic acid ethyl ester; In tetrahydrofuran; for 3h;