118198-35-9

Upstream product

• 111-02-4 2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene 
• 126652-04-8 (1-isopentyloxyethyl)diphenylphosphine oxide 
• 118198-26-8 (4E,8E,12E)-16-bromo-17-hydroxy-4,9,13,17-tetramethyloctadeca-4,8,12-trienal 
• 118198-32-6 1-(1-chloroethoxy)-3-methylbutane 
• 123-51-3 i-Amyl alcohol 
• 126652-02-6 (1-isopentyloxyethyl)triphenylphosphonium chloride 
• 56882-09-8 (4E,8E,12E)-4,9,13,17-Tetramethyloctadeca-4,8,12,16-tetraen-1-al 
• 65746-05-6 squalene monobromohydrin: 3-bromo-2,6,10,15,19,23-hexamethyl-6,10,14,18,22-tetracosapentaen-2-ol (all E) 

Relevant academic research and scientific papers

Stereospecific Synthesis of Squalenoid Epoxide Vinyl Ethers as Inhibitors of 2,3-Oxidosqualene Cyclase

The stereospecific synthesis of squalenoid epoxide vinyl ethers with an isopentyloxy group is described.The synthesis involves the preparation of the C22 squalenoid aldehyde bromohydrin (15) by a new method via a one-step cleavage of lipophilic epoxides using periodic acid in diethyl ether, and the preparation of (1-isopentyloxyethyl)diphenylphosphine oxide (24).The structure of this compound has been confirmed by X-ray analysis.The configuration of vinyl ethers, synthesized using a Wittig-Horner reaction, has been determined by (13)C n.m.r.Biological results show that vinyl ethers (5) and (27) are competitive inhibitors of 2,3-oxidosqualene cyclase from rat liver.