118248-06-9Relevant academic research and scientific papers
Peptidyl β-homo-aspartals: Specific inhibitors of interleukin-1β converting enzyme and its homologues (caspases)
Bajusz, Sandor,Fauszt, Iren,Nemeth, Klara,Barabas, Eva,Juhasz, Attila,Patthy, Miklos
, p. 1477 - 1482 (2007/10/03)
Inhibition of interleukin-1β convening enzyme (ICE), apopain, papain, thrombin and trypsin with substrate like peptidyl L- and D-α-aldehydes and their L-β-homo-aldehyde analogues was investigated. The L-β-homo-aspartals appear to be specific inhibitors fo
&β-Amino Acid Isomers of a Natural Substrate of the Enzyme &γ-Glutamyl-amino Acid Cyclotransferase. Synthesis of (3S)-3-Aminoglutaryl-(S)-alanine and (3R)-3-Aminoglutaryl-(S)-alanine
Crossley, Maxwell J.,Fisher, Megan L.,Potter, Jeffrey J.,Kuchel, Philip W.,York, Michael J.
, p. 2363 - 2369 (2007/10/02)
(3S)-3-Aminoglutaryl-(S)-alanine (8) and (3R)-3-aminoglutaryl-(S)-alanine (14), β-amino acid isomers of the dipeptide γ-glutamyl-(S)-alanine, a natural substrate of the enzyme γ-glutamyl-amino acid cyclotransferase, have been synthesized by two different
Synthesis of gastrin antagonists, analogues of the C-terminal tetrapeptide of gastrin, by introduction of a β-homo residue
Rodriguez,Fulcrand,Laur,Aumelas,Bali,Martinez
, p. 522 - 528 (2007/10/02)
A series of analogues of Boc-Trp-Leu-Asp-Phe-NH2, a potent gastrin agonist, were synthesized by introducing a β-homo residue in the sequence. These compounds were tested in vivo on acid secretion, in the anesthetized rat, and for their ability
