128117-73-7

Upstream product

• 2018-66-8 Z-Leu-OH 
• 102123-80-8 C₁₉H₂₇NO₆ 
• 142349-58-4 Methyl 5-(S)-N-(benzyloxycarbonyl)amino-2-methoxycarbonyl-7-methyl-4-oxooctanoate 
• 52467-54-6 Cbz-leucyl chloromethane 
• 102123-81-9 (3-diazo-1-(S)-(2-methylpropyl)-2-oxopropyl)carbamic acid benzyl ester 
• 118252-77-0 (3S)-3-<(benzyloxycarbonyl)amino>-1-bromo-5-methyl-2-oxohexane 
• 142349-60-8 2-Benzyl-2-((S)-3-benzyloxycarbonylamino-5-methyl-2-oxo-hexyl)-malonic acid dimethyl ester 

Downstream Products

• 142349-67-5 Z-LeuΨ(COCH2)(RS)Phe-OMe 
• 118405-11-1 ((S)-4-{(S)-1-[(S)-2-((S)-1-Benzylcarbamoyl-3-methyl-butylcarbamoyl)-1-hydroxy-ethyl]-3-methyl-butylcarbamoyl}-2-hydroxy-1-isobutyl-5-phenyl-pentyl)-carbamic acid benzyl ester 
• 142349-62-0 P-LeuΨ(COCH2)(RS)Phe-OMe 
• 142349-71-1 (BnO)2OP-LeuΨ(COCH2)(RS)Phe-OMe 

Relevant academic research and scientific papers

Ketomethylene analogues of phosphoryl dipeptides related to phosphoramidon: Synthesis and inhibition of proteases

Non-rhamnose-containing phosphoramidon analogues, in which the amide bond was replaced by the isosteric ketomethylene group, have been synthesized in order to stabilize these compounds to peptidase degradation. The key step in this synthesis was suitable

Renin inhibitors containing isosteric replacements of the amide bond connecting the P3 and P2 sites

Renin inhibitors having 13 different isosteres connecting the P3 and P2 positions have been prepared. Synthetic routes and in vitro activity exhibited by these compounds are discussed. The two most potent compounds, 47 and 48, contai

Inhibition of aminopeptidases by peptides containing ketomethylene and hydroxyethylene amide bond replacements

Inhibitors of aminopeptidase enzymes have been prepared by the synthesis of peptide substrate analogues in which the scissile amide bond has been replaced with the hydrolytically stable ketomethylene (-COCH2-) and hydroxyethylene [-CH(OH)CHsub