147124-32-1

Basic information

• Product Name: DIMETHYL 2-(4-CHLORO-2-NITROPHENYL)MALONATE
• Synonyms: DIMETHYL 2-(4-CHLORO-2-NITROPHENYL)MALONATE
• CAS NO: 147124-32-1
• Molecular Formula: C₁₁H₁₀ClNO₆
• Molecular Weight: 287.65
• Mol File: 147124-32-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 83-85°
• Boiling Point: 387.1±37.0 °C(Predicted)
• Appearance: /
• Density: 1.415±0.06 g/cm3(Predicted)
• Storage Temp.: Room temperature.
• PKA: 9.42±0.46(Predicted)
• CAS DataBase Reference: DIMETHYL 2-(4-CHLORO-2-NITROPHENYL)MALONATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIMETHYL 2-(4-CHLORO-2-NITROPHENYL)MALONATE(147124-32-1)
• EPA Substance Registry System: DIMETHYL 2-(4-CHLORO-2-NITROPHENYL)MALONATE(147124-32-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 147124-32-1(Hazardous Substances Data)

Usage

General Description

DIMETHYL 2-(4-CHLORO-2-NITROPHENYL)MALONATE is a chemical compound with the molecular formula C11H10ClNO6. It is a pale yellow powder that is insoluble in water but soluble in organic solvents. DIMETHYL 2-(4-CHLORO-2-NITROPHENYL)MALONATE is primarily used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and dyes. It is known to have potential applications in the field of organic chemistry due to its reactivity and versatility in forming carbon-carbon bonds. However, it is important to handle this compound with care as it is known to be harmful if swallowed, inhaled or comes into contact with the skin.

Upstream product

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• 147124-37-6 methyl 2-(4-chloro-2-nitrophenyl)acetate 

Relevant articles and documents

A Unified Catalytic Asymmetric (4+1) and (5+1) Annulation Strategy to Access Chiral Spirooxindole-Fused Oxacycles

A unified catalytic asymmetric (N+1) (N=4, 5) annulation reaction of oxindoles with bifunctional peroxides has been achieved in the presence of a chiral phase-transfer catalyst (PTC). This general strategy utilizes peroxides as unique bielectrophilic four- or five-atom synthons to participate in the C?C and the subsequent umpolung C?O bond-forming reactions with one-carbon unit nucleophiles, thus providing a distinct method to access the valuable chiral spirooxindole-tetrahydrofurans and -tetrahydropyrans with good yields and high enantioselectivities under mild conditions. DFT calculations were performed to rationalize the origin of high enantioselectivity. The gram-scale syntheses and synthetic utility of the resultant products were also demonstrated.

AN IMPROVED PROCESS FOR PREPARING 2-OXINDOLES OF FORMULA I, A KEY RAW MATERIAL FOR MAKING PHARMACEUTICAL DRUGS AND INTERMEDIATES THEREOF

The present invention provides an improved processes having practical utility for preparing 2-oxindoles of formula I comprising preparation of 2-nitroarylmalonate diester of formula II as first intermediate and subsequent insitu reductive cyclisation using metal acid combination and its modified work-up to form compound of formula I free from metal generated impurity of formula M(OH)X wherein M is metal cation and X is anion. R is selected from hydrogen, linear, branched or cyclic alkyl, aryl, substituted aryl, heteroaryl, haloalkyl like CF3, alkoxy, haloalkoxy, thioalkyl and halogen preferably chloro Formula I wherein R' and R" are same or different and is selected from linear.branched and cyclic alkyl (C1C4groups)preferably methyl R is selected from hydrogen, linear, branched or cyclic alkyl, aryl, substituted aryl, heteroaryl, haloalkyl like CF3, alkoxy, haloalkoxy, thioalkyl and halogen preferably chloro Formula II.

Asymmetic organocatalytic 1,3-dipolar cycloaddition of azomethine ylide to methyl 2-(2-nitrophenyl)acrylate for the synthesis of diastereoisomers of spirotryprostatin A

Chemical equations presented. The total synthesis of two diastereomers of spirotryprostatin A has been established starting with an asymmetric 1,3-dipolar cycloaddition of methyl 2-(2-nitrophenyl)acrylate with azomethine ylides catalyzed by a Bronsted aci