1183116-13-3Relevant articles and documents
NEW CRYSTAL OF BENZIMIDAZOLE COMPOUND, AND PRODUCTION METHOD THEREOF
-
, (2018/10/10)
PROBLEM TO BE SOLVED: To provide a new crystal of 2-[2-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-benzimidazole-5-yl]-1,3- benzoxazole having excellent storage stability capable of maintaining the same quality, when being stored as a pharmaceutical technical
Direct synthesis of a pde4 inhibitor by using pd-cu-catalyzed c-h/c-br coupling of benzoxazole with a heteroaryl bromide
Kuroda, Kiichi,Tsuyumine, Shinjiro,Kodama, Tomohiro
, p. 1053 - 1058 (2017/01/16)
A short and practical synthetic route of a PDE4 inhibitor (1) was established by using Pd-Cu-catalyzed C-H/ C-Br coupling of benzoxazole with a heteroaryl bromide. The combination of Pd(OAc)2-Cu(OTf)2-PPh3 was found to be