118358-66-0

Basic information

• Product Name: N-(9H-fluoren-9-ylmethoxycarbonyl)-D-serine benzyl ester
• Synonyms: N-(9H-fluoren-9-ylmethoxycarbonyl)-D-serine benzyl ester
• CAS NO: 118358-66-0
• Molecular Weight: 417.461
• Mol File: 118358-66-0.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: N-(9H-fluoren-9-ylmethoxycarbonyl)-D-serine benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(9H-fluoren-9-ylmethoxycarbonyl)-D-serine benzyl ester(118358-66-0)
• EPA Substance Registry System: N-(9H-fluoren-9-ylmethoxycarbonyl)-D-serine benzyl ester(118358-66-0)

Safety Data

• Hazardous Substances Data: 118358-66-0(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 73724-45-5 (R)-N-(fluoren-9-ylmethoxycarbonyl)serine 
• 212688-51-2 Fmoc-D-Ser(Trt)-OH 
• 866832-84-0 N-(9H-fluoren-9-ylmethoxycarbonyl)-O-trityl-D-serine benzyl ester 
• 558-43-0 2-Methyl-1,2-propanediol 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 73724-45-5 N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine 
• 100-51-6 benzyl alcohol 
• 171820-92-1 N-9-fluorenylmethoxycarbonyl-O-trityl-L-serine benzyl ester 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 60022-62-0 L-serine benzyl ester hydrochloride 
• 1738-72-3 L-serine benzyl ester 

Downstream Products

• 84010-48-0 benzyl-N-(fluorenylmethyloxycarbonyl)-O-(2,3,4,6-tetra-O-benzoyl β-D-glucopyranosyl) L-serinate 
• 118358-94-4 3-O-(2,3,4-Tri-O-acetyl-β-D-xylopyranosyl)-N-(fluorenylmethoxycarbonyl)-L-serin-benzylester 
• 84010-49-1 C₅₁H₄₃NO₁₂ 
• 118358-79-5 N-Fmoc-O-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl)-L-serine benzyl ester 
• 118358-37-5 N-9-fluorenylmethoxycarbonyl-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-L-serine benzyl ester 
• 100929-00-8 benzyl O-(3,4,6-tri-O-acetyl-2-azido-2-deoxy-α-D-galactopyranosyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-serinate 
• 337903-64-7 benzyl N-(9-fluorenylmethoxycarbonyl)-O-(3,4,6-tri-O-benzoyl-2-deoxy-2-[(2,2,2-trichloroethyloxycarbonyl)amino]-β-D-glucopyranosyl)-L-serinate 
• 1220982-48-8 Fmoc-serine(O-ethyl methylphosphonate) benzyl ester 
• 1220982-45-5 Fmoc-serine(O-isopropyl methylphosphonate) benzyl ester 
• 1220982-46-6 Fmoc-serine(O-pinacolyl methylphosphonate) benzyl ester 
• 1220982-47-7 Fmoc-serine(O-cyclohexyl methylphosphonate) benzyl ester 
• 1353654-63-3 4-(benzyloxy)-5-methylene-1H-pyrrol-2(5H)-one 
• 1353654-57-5 (S)-benzyl 2-amino-3-((triethylsilyl)oxy)propanoate 

Relevant articles and documents

Fluorescence-based detection of single nucleotide permutation in DNA via catalytically templated reaction

Templated reduction of low fluorescence azidocoumarin-PNA conjugate to high fluorescence aminocoumarin was achieved using a catalytic amount of DNA with single nucleotide resolution. The Royal Society of Chemistry.

In vitro synthesis of mucin-type O-glycans using saccharide primers comprising GalNAc-Ser and GalNAc-Thr residues

Mucin-type O-glycosylation of serine or threonine residue in proteins is known to be one of the major post-translational modifications. In this study, two novel alkyl glycosides, Nα-lauryl-O-(2-acetamido-2-deoxy-α-D-galactopyranosyl)-L-serineamide (GalNAc-Ser-C12) and Nα-lauryl-O-(2-acetamido-2-deoxy-α-D-galactopyranosyl)-L-threonineamide (GalNAc-Thr-C12) were synthesized as saccharide primers to prime mucin-type O-glycan biosynthesis in cells. Upon incubating human gastric cancer MKN45 cells with the saccharide primers, 22 glycosylated products were obtained, and their structures were analyzed using liquid chromatography-mass spectrometry and enzyme digestion. The amounts of glycosylated products were dependent on the amino acid residues in the saccharide primers. For example, in vitro synthesis of T antigen (Galβ1-3GalNAc), fucosyl-T (Fucα1-2Galβ1-3GalNAc), and sialyl-T (NeuAcα2-3Galβ1-3GalNAc) preferred a serine residue, whereas sialyl-Tn (NeuAcα2-6GalNAc) preferred a threonine residue. Furthermore, the glycosylated products derived from GalNAc-Ser/Thr-C12 and Gal-GalNAc-Ser/Thr-C12 using cell-free synthesis showed the same amino acid selectivity as those in the cell experiments. These results indicate that glycosyltransferases involved in the biosynthesis of mucin-type O-glycans distinguish amino acid residues conjugated to GalNAc. The saccharide primers developed in this study might be useful for comparing mucin-type oligosaccharides in cells and constructing oligosaccharide libraries to study cell function.

Amino acid derivative

The invention provides a novel amino acid derivative. The derivative is applied to modify a polypeptide drug to achieve the purposes of resisting degradation of a proteolytic enzyme and prolonging thehalf-life period of the drugs. The invention provides two methods for preparing the amino acid derivative.

COMPOSITIONS AND METHODS OF TREATING CANCER AND INFECTIONS USING BACTERIOPHAGE AND ITS MUTANTS

Provided herein are vaccine composition comprising an antigen conjugated to a capsid, wherein the capsid comprises wild type or native sequence. Provided herein are also vaccine composition comprising an antigen conjugated to a capsid, wherein said capsid comprises at least one mutation, such as a non-natural mutation. Such compositions are useful in the treatment and prevention of pathogenic infections, inflammatory diseases, and neurodegenerative disease, and cancer, among others.