1184181-89-2Relevant academic research and scientific papers
Stereoselective Synthesis of Dysoxylactam A
Chandankar, Somnath S.,Raghavan, Sadagopan
, p. 653 - 655 (2020)
The first report on the stereoselective synthesis of dysoxylactam A is disclosed. The five stereogenic centers of the fatty acid chain are created by utilizing Merck-Carreira and Marshall's propargylation reaction, Evans' alkylation methodology, and Noyor
Preparation method of vorapaxar and intermediates thereof
-
Paragraph 0031, (2017/07/20)
The invention relates to a preparation method of vorapaxar and intermediates thereof. The preparation method provided by the invention has no need for reducing carboxylic acid to aldehyde, directly oxidizes corresponding alcohol into corresponding aldehyde, is safe in operation, and avoids the harsh condition of using anhydrous palladium carbon in the existing technology that firstly carboxylic acid is converted into acyl chloride and then catalytic hydrogenation is carried out to obtain aldehyde through a palladium catalyst. The preparation method is simple, has simple operation steps, simplifies the reaction steps, and saves raw materials and reagents. The whole line is low in production cost and high in yield, thus being suitable for industrial production.
First stereoselective total synthesis and reconfirmation of absolute structure of nonenolide (?)-stagonolide D
Sravanth Kumar,Praneeth,Srihari,Yadav
, p. 509 - 511 (2017/01/16)
The first stereoselective total synthesis of nonenolide (?)-stagonolide D has been accomplished. Midland Alpine borane reduction to install hydroxyl group at C4, Henbest epoxidation to introduce epoxide stereoselectively between C7 and C8, Yamaguchi ester
Intramolecular imino Diels - Alder reaction: Progress toward the synthesis of uncialamycin
Desrat, Sandy,Van De Weghe, Pierre
supporting information; experimental part, p. 6728 - 6734 (2009/12/31)
(Chemical Equation Presented) We herein described an intramolecular imino Diels-Alder reaction promoted with BF3 3 OEt2/DDQ affording substituted quinolines. Using this procedure, we prepared the chiral quinoline moiety of the uncialamycin, a new enediyne natural product.
