118426-04-3

Basic information

• Product Name: 5-(4-BROMO-PHENYL)-2-(4-NITRO-PHENYL)-OXAZOLE
• Synonyms: 5-(4-BROMO-PHENYL)-2-(4-NITRO-PHENYL)-OXAZOLE
• CAS NO: 118426-04-3
• Molecular Formula: C₁₅H₉BrN₂O₃
• Molecular Weight: 345.15
• Product Categories: Oxazole&Isoxazole
• Mol File: 118426-04-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(4-BROMO-PHENYL)-2-(4-NITRO-PHENYL)-OXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-BROMO-PHENYL)-2-(4-NITRO-PHENYL)-OXAZOLE(118426-04-3)
• EPA Substance Registry System: 5-(4-BROMO-PHENYL)-2-(4-NITRO-PHENYL)-OXAZOLE(118426-04-3)

Safety Data

• Hazardous Substances Data: 118426-04-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Chemical Research:
5-(4-BROMO-PHENYL)-2-(4-NITRO-PHENYL)-OXAZOLE is used as a key intermediate in the development of new drugs and bioactive molecules, particularly for its potential in creating compounds with antibacterial, antifungal, and anticancer properties.
Used in Antibacterial Applications:
In the field of microbiology, 5-(4-BROMO-PHENYL)-2-(4-NITRO-PHENYL)-OXAZOLE is used as an antibacterial agent, leveraging its ability to inhibit the growth of various bacterial strains, thereby contributing to the development of new antimicrobial therapies.
Used in Antifungal Applications:
5-(4-BROMO-PHENYL)-2-(4-NITRO-PHENYL)-OXAZOLE is utilized as an antifungal agent, effective against a range of fungal species, which is crucial in the treatment of fungal infections and the development of antifungal medications.
Used in Anticancer Applications:
In oncology, 5-(4-BROMO-PHENYL)-2-(4-NITRO-PHENYL)-OXAZOLE is employed as an anticancer agent, showing potential in targeting and inhibiting the growth of cancer cells, making it a candidate for further research in cancer treatment.
Used in Bioimaging as a Fluorescent Probe:
5-(4-BROMO-PHENYL)-2-(4-NITRO-PHENYL)-OXAZOLE is used as a fluorescent probe in bioimaging, capitalizing on its optical properties to visualize cellular and molecular processes, aiding in the advancement of diagnostic techniques in biological and medical research.
Used in Materials Science and Optoelectronics:
In the realm of materials science and optoelectronics, 5-(4-BROMO-PHENYL)-2-(4-NITRO-PHENYL)-OXAZOLE is used for its potential applications in the development of new materials with specific optical, electronic, and sensing properties, contributing to innovations in various technological applications.

Upstream product

• 96907-75-4 1-(4-nitrophenyl)-4-(4-bromophenyl)-2-aza-1,4-butanedione 
• 5467-72-1 α-amino-4-bromoacetophenone hydrochloride 
• 122-04-3 4-nitro-benzoyl chloride 
• 766-96-1 4-bromo-1-ethynylbenzene 
• 2733-41-7 4-nitrobenzoyl azide 

Downstream Products

• 89752-95-4 4-[5-(4-Bromo-phenyl)-oxazol-2-yl]-phenylamine 
• 1313751-65-3 C₂₈H₁₉N₃O₃ 
• 1313751-66-4 C₁₅H₁₁N₃O₃ 

Relevant articles and documents

Reaction of alkynes and azides: Not triazoles through copper-acetylides but oxazoles through copper-nitrene intermediates

Well-defined copper(I) complexes of composition [Tpm* ,BrCu(NCMe)]BF4 (Tpm*,Br=tris(3,5- dimethyl-4-bromo-pyrazolyl)methane) or [Tpa* Cu]PF6 (Tpa=tris(3,5-dimethyl-pyrazolylmethyl)amine) catalyze the formation of 2,5-disubstituted oxazoles from carbonyl azides and terminal alkynes in a direct manner. This process represents a novel procedure for the synthesis of this valuable heterocycle from readily available starting materials, leading exclusively to the 2,5-isomer, attesting to a completely regioselective transformation. Experimental evidence and computational studies have allowed the proposal of a reaction mechanism based on the initial formation of a copper-acyl nitrene species, in contrast to the well-known mechanism for the copper-catalyzed alkyne and azide cycloaddition reactions (CuAAC) that is triggered by the formation of a copper-acetylide complex.

HEPATITIS C VIRUS INHIBITORS

The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the function of the NS5A protein

SYNTHESIS AND STUDY OF THE TRANSFER OF SUBSTITUENT ELECTRONIC EFFECTS IN SUBSTITUTED 2,5-DIPHENYLOXAZOLES

A series of para-substituted 2,5-diphenyloxazoles was synthesized using Robinson-Gabriel procedure and the transfer of substituent electronic effects in these compounds was examined.